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Analytical studies on some prodrugs / Eman Mohamed Moaaz Mohamed Emara ; Supervised Ezzat Mohamed Abdelmoety , Mamdouh Reda Rezk , Ahmed Salah Fayed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Eman Mohamed Moaaz Mohamed Emara , 2021Description: 143 P. : charts , facsimiles ; 25cmOther title:
  • دراسات تحليلية على بعض الأدوية الأولية [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry Summary: This thesis is concerned with the quantitative determination of some prodrugs. In this thesis, two prodrugs (tedizolid phosphate and acemetacin) were studied separately as targeted analytes. The first prodrug, tedizolid phosphate, is an antibiotic that is bio-activated to tedizolid by phosphatase enzymes.The second drug, acemetacin, is an analgesic non-steroidal anti-inflammatory drug that is bio-activated to indomethacin by liver enzymes.The aim of this work was to develop different analytical methods which are characterized by simplicity, accuracy and appropriate degree of sensitivity for the analysis of the above-mentioned prodrugs in their powdered form, in the presence of dosage-form excipients, active metabolites and possible degradation products. Two stability-indicating chromatographic methods, simple fluorimetric and ion selective electrode based potentiometric methods were developed for the sensitive analysis of tedizolid phosphate.Tedizolid was confirmed to be the major degradant of tedizolid phosphate obtained by simple neutral degradation of the parent drug. Acemetacin was assayed by different chromatographic, fluorimetric and electrochemical (voltammetry and ion selective electrode) methods
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.M.Sc.2021.Em.A (Browse shelf(Opens below)) Not for loan 01010110084364000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.M.Sc.2021.Em.A (Browse shelf(Opens below)) 84364.CD Not for loan 01020110084364000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

This thesis is concerned with the quantitative determination of some prodrugs. In this thesis, two prodrugs (tedizolid phosphate and acemetacin) were studied separately as targeted analytes. The first prodrug, tedizolid phosphate, is an antibiotic that is bio-activated to tedizolid by phosphatase enzymes.The second drug, acemetacin, is an analgesic non-steroidal anti-inflammatory drug that is bio-activated to indomethacin by liver enzymes.The aim of this work was to develop different analytical methods which are characterized by simplicity, accuracy and appropriate degree of sensitivity for the analysis of the above-mentioned prodrugs in their powdered form, in the presence of dosage-form excipients, active metabolites and possible degradation products. Two stability-indicating chromatographic methods, simple fluorimetric and ion selective electrode based potentiometric methods were developed for the sensitive analysis of tedizolid phosphate.Tedizolid was confirmed to be the major degradant of tedizolid phosphate obtained by simple neutral degradation of the parent drug. Acemetacin was assayed by different chromatographic, fluorimetric and electrochemical (voltammetry and ion selective electrode) methods

Issued also as CD

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