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Analytical studies of some drugs containing amide group and its mono-acyl derivative / Aya Hosam Helmy ; Supervised Badr A. Elzeiny , Soheir A. Ahmed , Nadia F. Youssef

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Aya Hosam Helmy , 2021Description: 163 P. : charts , facsimiles ; 25cmOther title:
  • دراسات تحليلية لبعض الادويه التى تحتوى على مجموعه الاميد ومشتقها احادى الاسيل [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry Summary: The health and the safety of pharmaceutical products consumers are protected by the national control laboratories. Prior the pharmaceutical product is approved to the market several tests must be applied to ensure that these products meet the accepted standard of quality, efficacy and safety. However, time consuming method is usually stood as barrier to achieve fast results. Moreover, developing country laboratories are suffering from deficiency of sophisticated analytical instruments. This study concerned with developing fast, simple, inexpensive and accurate accessible analytical methods using chromatographic and spectroscopic techniques for the simultaneous determination of selected drugs containing amide group like perampanel and carbamazepine or its mono-acyl derivative like aniracetam. Stability-indicating chromatographic methods were applied to determine aniracetam in presence of its degradation products using 25 cm, C18 column with limit of detection of 0.216 æg/ml for HPLC method, 0.009 æg/band for NP-TLC and 0.008 for RP-TLC methods. Comparative kinetics studies and pH rate-profile were applied to determine the rate and order of degradation reaction using the developed HPLC-UV method. Spectroflourimetric method was used to determine aniracetam by fluorescence quenching of tyrosine and L-tryptophan fluorescent amino acids with LOD 0.104æg/ml and 0.140æg/ml, respectively
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.Ph.D.2021.Ay.A (Browse shelf(Opens below)) Not for loan 01010110084399000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.Ph.D.2021.Ay.A (Browse shelf(Opens below)) 84399.CD Not for loan 01020110084399000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

The health and the safety of pharmaceutical products consumers are protected by the national control laboratories. Prior the pharmaceutical product is approved to the market several tests must be applied to ensure that these products meet the accepted standard of quality, efficacy and safety. However, time consuming method is usually stood as barrier to achieve fast results. Moreover, developing country laboratories are suffering from deficiency of sophisticated analytical instruments. This study concerned with developing fast, simple, inexpensive and accurate accessible analytical methods using chromatographic and spectroscopic techniques for the simultaneous determination of selected drugs containing amide group like perampanel and carbamazepine or its mono-acyl derivative like aniracetam. Stability-indicating chromatographic methods were applied to determine aniracetam in presence of its degradation products using 25 cm, C18 column with limit of detection of 0.216 æg/ml for HPLC method, 0.009 æg/band for NP-TLC and 0.008 for RP-TLC methods. Comparative kinetics studies and pH rate-profile were applied to determine the rate and order of degradation reaction using the developed HPLC-UV method. Spectroflourimetric method was used to determine aniracetam by fluorescence quenching of tyrosine and L-tryptophan fluorescent amino acids with LOD 0.104æg/ml and 0.140æg/ml, respectively

Issued also as CD

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