Preparation of an anti-inflammatory drug in different dosage forms for topical application / Dalia Ali Farghaly Ibrahim ; Supervised Magdy Ibrahim Mohamed , Ahmed Abdelfattah Aboelwafa , Manal Yassin Hamza

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

The aim of this study was to formulate fenoprofen calcium (FPCa) in different topical dosage forms; namely microemulsion and spanlastic gel to eliminate its oral gastrointestinal adverse effects. Microemulsion was prepared by the water titration method using oleic acid as oil phase, tween 80 or cremophor EL as surfactants and propylene glycol or transcutol P as cosurfactants. Oleic acid was selected as oil phase due to its good solubilizing capacity. Microemulsion existence region was determined using pseudo-ternary phase diagrams for preparing different formulations. Six different formulations were selected with various values of oil (25-68%), water (2-3%), and the mixture of tween 80 and propylene glycol (1:1) (24-67%). The selected microemulsion formulae were characterized for optical birefringence, transmission electron microscopy, pH, % transmittance, electronic conductivity, drug content, droplet size, rheological properties and stability evaluation. In-vitro release study of fenoprofen calcium from microemulsions through the synthetic membrane and hairless rat skin were evaluated. The optimized formula ME5 consisting of 5% w/w fenoprofen calcium, 60% w/w oleic acid as oil phase, 3% w/w aqueous phase, and 32% w/w of surfactant phase containing Tween 80 and propylene glycol (1:{u2009}1) showed the highest transdermal flux and highest skin permeation rate. FPCa-loaded spanlastics were prepared by thin-film hydration (TFH) technique according to a full factorial design (23) to investigate the influence of formulation variables on the drug entrapment efficiency (%EE), particle size (PS), deformability index (DI), and the % drug released after 24hs through the cellulose membrane (Q24h) using design-expert® software

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