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Molecular characterization for some single nucleotide polymorphisms in the dipeptidy1 peptidase 1 (DPPI) gene / Ghada Mohamed Abdelhaleem Elfeki ; Supervised Mohamed A. Badway , Mohamed A. Eldesouky , Andrew F. Walls

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ghada Mohamed Abdelhaleem Elfeki , 2015Description: 111 P. : charts , facsimiles ; 25cmOther title:
  • توصيف جزيئى للطفرات أحادية القاعده النيتروجينيه الموجوده فى الجين المسئول عن انزيم تحلل ثنائى الرابطه البيبتيديه [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry Summary: Asthma is caused by immune response to environmental stimuli, an effect in which there is airway remodelling. When individuals come in contact with stimuli, their bronchi become inflamed. The inflammatory response is triggered by a chain reaction initiated by several effector molecules. One of these molecules is cathepsin C (CTSC). A mutation within this gene could provide protection against the inflammatory response. Three hundred forty one families, each with at least two siblings with asthma were genotyped for two CTSC polymorphisms (rs217086 (T153I) AND rs3888798 (I453V)) using high resolution melting curve analysis. Genetic association analysis was analysed using family based association tests (FBAT) and resultant called genotypes were sequenced. DNA sequence data confirmed all variant genotypes. Analysis by FBAT showed no significant association between any polymorphisms and asthma susceptibility or with any of asthma-related phenotypes tested. This study failed to confirm a substantial role of the T153I and I453V, CTSC polymorphisms in the genetic predisposition for atopic asthma in a large UK family-based asthma cohort
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.M.Sc.2015.Gh.M (Browse shelf(Opens below)) Not for loan 01010110067254000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.M.Sc.2015.Gh.M (Browse shelf(Opens below)) 67254.CD Not for loan 01020110067254000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry

Asthma is caused by immune response to environmental stimuli, an effect in which there is airway remodelling. When individuals come in contact with stimuli, their bronchi become inflamed. The inflammatory response is triggered by a chain reaction initiated by several effector molecules. One of these molecules is cathepsin C (CTSC). A mutation within this gene could provide protection against the inflammatory response. Three hundred forty one families, each with at least two siblings with asthma were genotyped for two CTSC polymorphisms (rs217086 (T153I) AND rs3888798 (I453V)) using high resolution melting curve analysis. Genetic association analysis was analysed using family based association tests (FBAT) and resultant called genotypes were sequenced. DNA sequence data confirmed all variant genotypes. Analysis by FBAT showed no significant association between any polymorphisms and asthma susceptibility or with any of asthma-related phenotypes tested. This study failed to confirm a substantial role of the T153I and I453V, CTSC polymorphisms in the genetic predisposition for atopic asthma in a large UK family-based asthma cohort

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