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Effect of cyclin D1 on the prognosis of multiple myeloma in Egyptian patients / Menna Alla Mohie Eldein Elsayed Sherif ; Supervised Lalia Abdelrahman Hegazy , Osman Mohamed Mansour , Reham Ahmed Rashed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Menna Alla Mohie Eldein Elsayed Sherif , 2018Description: 129 P. : charts , facsimiles ; 25cmOther title:
  • على التطور الأكلينيكى فى المرضى المصريين المصابين بالورم النقوى المتعدد D1 تأثير السيكلين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background: Multiple myeloma is a disseminated malignancy of monoclonal plasma cells, diagnosed by {u2265}10% clonal bone marrow plasma cells or a biopsy infiltrated by plasma cells along with one or more of the multiple myeloma defining events (MDE): CRAB (hypercalcemia, renal failure, anemia, or lytic bone lesions). Aim of work: Correlating Cyclin D1 with the prognosis of the patients. Subjects, materials and methods: Bone marrow biopsy of 50 patients newly diagnosed as Multiple myeloma were examined by immunohistochemistry for Cyclin D1, then these patients were followed up for a year. Results: There was significant correlation between Cyclin D1 and response of the patients. Conclusion: Cyclin D1 positive patients were found more likely to have worse prognosis than the negative ones
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Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background: Multiple myeloma is a disseminated malignancy of monoclonal plasma cells, diagnosed by {u2265}10% clonal bone marrow plasma cells or a biopsy infiltrated by plasma cells along with one or more of the multiple myeloma defining events (MDE): CRAB (hypercalcemia, renal failure, anemia, or lytic bone lesions). Aim of work: Correlating Cyclin D1 with the prognosis of the patients. Subjects, materials and methods: Bone marrow biopsy of 50 patients newly diagnosed as Multiple myeloma were examined by immunohistochemistry for Cyclin D1, then these patients were followed up for a year. Results: There was significant correlation between Cyclin D1 and response of the patients. Conclusion: Cyclin D1 positive patients were found more likely to have worse prognosis than the negative ones

Issued also as CD

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