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Synthesis and biological evaluation of some novel coumarin derivatives of expected cholinesterase inhibitory activity / Mennat Allah Mohammed Mahmoud Elsawah ; Supervised Kamilia Mahmoud Amin , Yassin Mohammed Nissan , Walaa Ramadan Mahmoud

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mennat Allah Mohammed Mahmoud Elsawah , 2018Description: 161 P. ; 25cmOther title:
  • التشييد و التقييم الحيوى لبعض مشتقات الكومارين الجديدة المتوقع لها نشاط مثبط لإنزيم الكولين إستريز [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: Coumarin is an interesting bioactive scaffold eliciting a wide range of biological activities including anticancer, antibacterial, anti-inflammatory, antihypertensive and anticonvulsant activity. Herein, we highlighted on the acetylcholinesterase inhibitory activity of the coumarin nucleus notably 6-aminocoumarin derivatives which were reported to possess acetylcholinesterase inhibitory activity and many of them are in clinical trials. In this work, six series of 6-aminocoumarin-based compounds were synthesized. The target compounds featured a variety of bioactive chemical fragments of CNS action. Acetylcholinesterase inhibitory activity study was performed for all synthesized compounds. Furthermore, in silico studies were performed on the synthesized compounds which included molecular docking study at the active site of AChE enzyme as well as prediction of their pharmacokinetic parameters
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2018.Me.S (Browse shelf(Opens below)) Not for loan 01010110077229000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2018.Me.S (Browse shelf(Opens below)) 77229.CD Not for loan 01020110077229000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

Coumarin is an interesting bioactive scaffold eliciting a wide range of biological activities including anticancer, antibacterial, anti-inflammatory, antihypertensive and anticonvulsant activity. Herein, we highlighted on the acetylcholinesterase inhibitory activity of the coumarin nucleus notably 6-aminocoumarin derivatives which were reported to possess acetylcholinesterase inhibitory activity and many of them are in clinical trials. In this work, six series of 6-aminocoumarin-based compounds were synthesized. The target compounds featured a variety of bioactive chemical fragments of CNS action. Acetylcholinesterase inhibitory activity study was performed for all synthesized compounds. Furthermore, in silico studies were performed on the synthesized compounds which included molecular docking study at the active site of AChE enzyme as well as prediction of their pharmacokinetic parameters

Issued also as CD

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