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A pharmaceutical study on mosapride for intranasal administration / Reham Waheed Mahmoud Hammad ; Supervised Nevine Shawky Abdelmalak , Randa Latif Aziz , Rania Abdelbaset Sanad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Reham Waheed Mahmoud Hammad , 2019Description: 229 P. : charts ; 25cmOther title:
  • دراسة صيدلية علي عقار الموزابريد لاستخدامة عن طريق الانف [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Industrial Pharmacy Summary: Mosapride citrate (MOS) is a potent gastroprokinetic agent, used in the treatment of various gastrointestinal disorders caused by reduced gastrointestinal motility including gastroesophageal reflux disease (GERD). MOS would neither result in cardiac nor nervous adverse reactions due to selective stimulation of serotonin 5-HT4 receptors, without any considerable affinity for dopamine D2, 5-HT1, 5-HT2, or adrenergic receptors. Presently, available tablet dosage formulation of MOS is incapable to achieve the required clinical efficacy. Its short half-life (t1/2), intensive first-pass metabolism, poor solubility, and poor wettability lower its oral bioavailability to be 8-14%.This very low oral bioavailability restricts its use. So, the aim of this study was to improve the bioavailability MOS through intranasal administration
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.10.M.Sc.2019.Re.P (Browse shelf(Opens below)) Not for loan 01010110078664000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.10.M.Sc.2019.Re.P (Browse shelf(Opens below)) 78664.CD Not for loan 01020110078664000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Industrial Pharmacy

Mosapride citrate (MOS) is a potent gastroprokinetic agent, used in the treatment of various gastrointestinal disorders caused by reduced gastrointestinal motility including gastroesophageal reflux disease (GERD). MOS would neither result in cardiac nor nervous adverse reactions due to selective stimulation of serotonin 5-HT4 receptors, without any considerable affinity for dopamine D2, 5-HT1, 5-HT2, or adrenergic receptors. Presently, available tablet dosage formulation of MOS is incapable to achieve the required clinical efficacy. Its short half-life (t1/2), intensive first-pass metabolism, poor solubility, and poor wettability lower its oral bioavailability to be 8-14%.This very low oral bioavailability restricts its use. So, the aim of this study was to improve the bioavailability MOS through intranasal administration

Issued also as CD

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