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Evaluation of cell responses against hepatitis C virus antigens among Egyptian healthcare workers at high risk of infection / Zainab Zakaria Ali Zenhom ; Supervised Mahmoud Ahmed Amer , Sayed Fekry Abdelwahab

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Zainab Zakaria Ali Zenhom , 2014Description: 171 P. : charts , facsimiles ; 25cmOther title:
  • تقييم رد الفعل الخلوى ضد أنتيجينات فيروس الإلتهاب الكبدى (سى) بين العاملين المصريين فى مجال الرعاية الصحية و المعرضين لمخاطر عالية من الإصابة بالعدوى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology Summary: Hepatitis C Virus (HCV) specific cell-mediated immunity (CMI) has been reported among exposed individuals without viremia or seroconversion. Limited data are available regarding CMI among at - risk, seronegative, aviremic Egyptian healthcare workers (HCW), where HCV genotype 4 predominates. We investigated CMI responses among HCW at the National liver institute, where over 85% of the patients are HCV - infected. We quantified HCV - specific CMI in 52 seronegative aviremic Egyptian HCW using an interferon gamma (IFN - Þ) enzyme-linked immunospot (ELISpot) assay in response to 7 HCV genotype 4a overlapping 15mer peptide pools covering most of the viral genome. We also characterized the phenotype of the responding T cells to the HCV peptide pools by flow cytometry
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2014.Za.E (Browse shelf(Opens below)) Not for loan 01010110064593000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2014.Za.E (Browse shelf(Opens below)) 64593.CD Not for loan 01020110064593000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology

Hepatitis C Virus (HCV) specific cell-mediated immunity (CMI) has been reported among exposed individuals without viremia or seroconversion. Limited data are available regarding CMI among at - risk, seronegative, aviremic Egyptian healthcare workers (HCW), where HCV genotype 4 predominates. We investigated CMI responses among HCW at the National liver institute, where over 85% of the patients are HCV - infected. We quantified HCV - specific CMI in 52 seronegative aviremic Egyptian HCW using an interferon gamma (IFN - Þ) enzyme-linked immunospot (ELISpot) assay in response to 7 HCV genotype 4a overlapping 15mer peptide pools covering most of the viral genome. We also characterized the phenotype of the responding T cells to the HCV peptide pools by flow cytometry

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