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Impact of RAGE gene polymorphism in patients with type 2 diabetes complicated with diabetic nephropathy / By Manar Ahmed Abdel Aziz Mansi; Under Supervision of Prof. Dr. Hala Essam Eldin Mohamed Kahla, Prof. Dr. Aamal Ahmed Mohamed, Dr. Rasha Sobh Mohamed, Dr. Yasmin Abdel Fattah Mohamed

By: Contributor(s): Material type: TextTextLanguage: English Summary language: English, Arabic Producer: 2024Description: 92 pages : illustrations ; 25 cm. + CDContent type:
  • text
Media type:
  • Unmediated
Carrier type:
  • volume
Other title:
  • مدى التحور الجيني لمستقبل المنتجات النهائية للجلكزة المتقدمة (RAGE) في مرضى النوع 2 من البول السكري، وأثره على اعتلال الكلى السكري [Added title page title]
Subject(s): DDC classification:
  • 616.466
Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D)-Cairo University, 2024. Summary: The development of genetic biomarkers in different chronic diseases has focused on assisting in diagnosis and monitoring disease complications. Receptor for advanced glycated end products (RAGE) gene polymorphism has been implicated previously in type 2 diabetes mellitus pathophysiology and its complications, particularly diabetic nephropathy. Objective: To assess single nucleotide polymorphism (SNP) of RAGE gene at rs 1800625 (-429 T> C) among type 2 diabetic patients and to investigate the relationship between this polymorphism and diabetic nephropathy. Methods: In a case control analytical study including 370 subjects; 185 T2DM patients complicated with nephropathy and 185 T2DM patients without nephropathy as control subjects. All T2DM patients were subjected to assessment of nephropathy according to ACR, serum creatinine and e-GFR and assessment of gene polymorphism at rs 1800625 (-429T > C). Outcome measures: to assess the relation between RAGE gene polymorphism and Diabetic nephropathy in T2DM. Results: there was no significant difference between the 2 groups of our study (T2DM with and without nephropathy) regarding Allelic discrimination of RAGE gene at rs 1800625 (-429T > C). Also, there was no statistically significant relation between ACR, e-GFR, serum creatinine, FBS, HBA1C and allelic discrimination of RAGE gene at rs1800625 -429 T > C. Conclusion: There was no association between rage gene polymorphism at rs 1800625 (-429T > C) and diabetic nephropathy in type 2 diabetes mellitus.Summary: الهدف من هذه الدراسة هو الكشف عن تعدد أشكال أحادي النوكليوتيداتSNP)) في جين RAGE عند rs1800624 في مرضى السكري من النوع 2 وعلاقته باعتلال الكلى السكري. أجريت دراسة الحالة والشواهد هذه على 370 مريضًا بالسكري من النوع 2 مصاب أو غير مصاب باعتلال الكلى السكري (185 مريضا في كل مجموعة). النتائج: لم يكن هناك فرق كبير بين مجموعتين من دراستنا (T2DM مصاب أو غير مصاب باعتلال الكلى) من حيث تعدد الأشكال لجين الـ RAGE عند rs 1800625 (-429T>C). وعليه استنتجنا أنه لا يوجد ارتباط بين تعدد أشكال جين الـRAGE عند rs 1800625 -429T>C واعتلال الكلى السكري في داء السكري من النوع 2.
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.Ph.D.2024.Ma.I. (Browse shelf(Opens below)) Not for loan 01010110091107000

Thesis (Ph.D)-Cairo University, 2024.

Bibliography: pages 200-250.

The development of genetic biomarkers in different chronic diseases has
focused on assisting in diagnosis and monitoring disease complications.
Receptor for advanced glycated end products (RAGE) gene
polymorphism has been implicated previously in type 2 diabetes mellitus
pathophysiology and its complications, particularly diabetic nephropathy.
Objective: To assess single nucleotide polymorphism (SNP) of RAGE
gene at rs 1800625 (-429 T> C) among type 2 diabetic patients and to
investigate the relationship between this polymorphism and diabetic
nephropathy.
Methods: In a case control analytical study including 370 subjects; 185
T2DM patients complicated with nephropathy and 185 T2DM patients
without nephropathy as control subjects. All T2DM patients were
subjected to assessment of nephropathy according to ACR, serum
creatinine and e-GFR and assessment of gene polymorphism at rs
1800625 (-429T > C).
Outcome measures: to assess the relation between RAGE gene
polymorphism and Diabetic nephropathy in T2DM.
Results: there was no significant difference between the 2 groups of our
study (T2DM with and without nephropathy) regarding Allelic
discrimination of RAGE gene at rs 1800625 (-429T > C). Also, there
was no statistically significant relation between ACR, e-GFR, serum
creatinine, FBS, HBA1C and allelic discrimination of RAGE gene at
rs1800625 -429 T > C.
Conclusion: There was no association between rage gene polymorphism
at rs 1800625 (-429T > C) and diabetic nephropathy in type 2 diabetes
mellitus.

الهدف من هذه الدراسة هو الكشف عن تعدد أشكال أحادي النوكليوتيداتSNP)) في جين RAGE عند rs1800624 في مرضى السكري من النوع 2 وعلاقته باعتلال الكلى السكري. أجريت دراسة الحالة والشواهد هذه على 370 مريضًا بالسكري من النوع 2 مصاب أو غير مصاب باعتلال الكلى السكري (185 مريضا في كل مجموعة).
النتائج: لم يكن هناك فرق كبير بين مجموعتين من دراستنا (T2DM مصاب أو غير مصاب باعتلال الكلى) من حيث تعدد الأشكال لجين الـ RAGE عند rs 1800625 (-429T>C).
وعليه استنتجنا أنه لا يوجد ارتباط بين تعدد أشكال جين الـRAGE عند rs 1800625 -429T>C واعتلال الكلى السكري في داء السكري من النوع 2.

Issued also as CD

Text in English and abstract in Arabic & English.

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