Cancer tumors growth factor polymorphisms in patients with systemic lupus erythematosus / Dina Mohamed Mekawi Rabie ; Supervised Laila Ahmed Rashed , Abeer Nabeel Mokbel , Nermeen Mohamed Hassan
Material type: TextLanguage: English Publication details: Cairo : Dina Mohamed Mekawi Rabie , 2014Description: 131 P. : charts ; 25cmOther title:- الانواع الجينية لعامل النمو المبطن للاوعية الدموية فى مرضى الذئبة الحمراء [Added title page title]
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Item type | Current library | Home library | Call number | Copy number | Status | Date due | Barcode | |
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Thesis | قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.11.03.M.Sc.2014.Di.V (Browse shelf(Opens below)) | Not for loan | 01010110064001000 | |||
CD - Rom | مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.11.03.M.Sc.2014.Di.V (Browse shelf(Opens below)) | 64001.CD | Not for loan | 01020110064001000 |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Medical Biochemistry
Background: VEGF has a role in various diseases involving endothelial cells including lupus glomerulonephritis caused by immune complex deposition.Objectives: to study the association between VEGF polymorphism with susceptibility to SLE as well as lupus nephritis and its relation to VEGF protein level.subjects and methods:Acase control study involving 40 SLE patients without nephritis and 40 SLE patients with nephritis and 20 healthy controls. Polymerase chain reaction and restriction fragment lenght polymorphism(PCR- RFLP)methods were applied to detect polymorphism in VEGF promoter +405 and -460 and VEGF protein level was measured by ELISA.Results:. There was a significant difference in the VEGF 405 GG (52.5%) and VEGF TT 460 (57.5%) genotypes in lupus nephritis patients compared to the control subjects (35%) ,(45%) respectively
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