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Impact of microbial infection on epithelial mesenchymaltransition mechanism as a vehicle of bladder cancer metastasis : A molecular biology study / Romaila Ahmed Mahmoud Abdeleraouf ; Supervised Salama A. Ouf , Bedier Alieldien Elbaz , Khaled Fawzy Alyasargy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Romaila Ahmed Mahmoud Abdeleraouf , 2021Description: 188 P. : charts , facsmilies ; 25cmOther title:
  • دراسة جزيئية : تأثير العدوي الميكروبية على آلية تحول خلايا الظاهرية الى خلايا وسيطة كوسيلة لانتشار مرض سرطان المثانة البولية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Botany and Microbiology Summary: ROS levels are triggered in cancer cells because of bacteria that led to increase in UCP2 to adjust ROS levels. This enhances PDK1 to downregulate PDH in order to block OXPHOS in favor of glycolysis. That results in aberration in mitochondrial function and decrease of AMPK enzyme, while MCT1 elevates to be able to export the produced lactate to ECM. ECM now became more acidic and ready for morphological changes. This process occurs concomitantly with EMT as it provides the cell rapid ATP and energy required for transdifferentiation like EMT and stemness
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.05.Ph.D.2021.Ro.I (Browse shelf(Opens below)) Not for loan 01010110082918000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.05.Ph.D.2021.Ro.I (Browse shelf(Opens below)) 82918.CD Not for loan 01020110082918000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Botany and Microbiology

ROS levels are triggered in cancer cells because of bacteria that led to increase in UCP2 to adjust ROS levels. This enhances PDK1 to downregulate PDH in order to block OXPHOS in favor of glycolysis. That results in aberration in mitochondrial function and decrease of AMPK enzyme, while MCT1 elevates to be able to export the produced lactate to ECM. ECM now became more acidic and ready for morphological changes. This process occurs concomitantly with EMT as it provides the cell rapid ATP and energy required for transdifferentiation like EMT and stemness

Issued also as CD

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