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Role of long non coding rnas expression in development of atherosclerosis in Egyptian systemic lupus erythematosus patients / Mai Ahmed Abdelmawla ; Supervised Amira A. Shaheen , Sherine M. Rizk , Mary W. Fawzy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mai Ahmed Abdelmawla , 2018Description: 77 P. : charts , facsimiles ; 25cmOther title:
  • دور التعبير الجيني لجزيئات الحمض النووي الريبوزي الطويلة غير المشفرة للبروتينات وإرتباطه بنشوء تصلب الشرايين عند مرضي الذئبة الحمراء المصريين [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry Summary: Although long non-coding RNAs (lncRNAs) have emerged as potential regulators in the development of atherosclerosis, their precise role in setting of this complication in systemic lupus erythematosus (SLE) is largely unknown. So our study aimed to quantify the expression level of three lncRNAs which are known to be relevant to atherosclerosis (ANRIL, NOS3-AS and APOA1-AS) in Egyptian SLE patients and to assess their relationship with atherogenic and inflammatory biomarkers. The circulating levels of these lncRNAs were assessed using RT-PCR, in addition to measurement of E-selectin, V-CAM1, oxidized low density lipoprotein (oxLDL), total nitric oxide (NOx) and lipid profile in 65 SLE patients (35 atherosclerotic and 30 non atherosclerotic) beside 35 healthy control subjects of matched age and sex. The expression levels of these lncRNAs were higher in SLE patients than in healthy controls. Importantly, a higher over-expression of these lncRNAs was noticed in atherosclerotic SLE patients than in non atherosclerotic ones
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2018.Ma.R (Browse shelf(Opens below)) Not for loan 01010110078362000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2018.Ma.R (Browse shelf(Opens below)) 78362.CD Not for loan 01020110078362000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

Although long non-coding RNAs (lncRNAs) have emerged as potential regulators in the development of atherosclerosis, their precise role in setting of this complication in systemic lupus erythematosus (SLE) is largely unknown. So our study aimed to quantify the expression level of three lncRNAs which are known to be relevant to atherosclerosis (ANRIL, NOS3-AS and APOA1-AS) in Egyptian SLE patients and to assess their relationship with atherogenic and inflammatory biomarkers. The circulating levels of these lncRNAs were assessed using RT-PCR, in addition to measurement of E-selectin, V-CAM1, oxidized low density lipoprotein (oxLDL), total nitric oxide (NOx) and lipid profile in 65 SLE patients (35 atherosclerotic and 30 non atherosclerotic) beside 35 healthy control subjects of matched age and sex. The expression levels of these lncRNAs were higher in SLE patients than in healthy controls. Importantly, a higher over-expression of these lncRNAs was noticed in atherosclerotic SLE patients than in non atherosclerotic ones

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