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Association analysis of FTO gene polymorphism and obesity risk among Egyptian children and adolescents / Samar Samir Abdelrahman Abdelmajed Elkhateeb ; Supervised Mohamed Mohamed Mohamed Yousef , Somaia Mohamed Ismail

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Samar Samir Abdelrahman Abdelmajed Elkhateeb , 2018Description: 93 P. : charts , facsimiles ; 25cmOther title:
  • و خطر الإصابة بمرض السمنة بين الأطفال والمراهقين المصريين FTO تحليل الارتباط ما بين التعدد الشكلى فى جين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology Summary: Background: Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity-associated (FTO) gene and obesity in adults and children in different ethnic groups. Objective: In our study, the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and adolescents. Subjects and methods: We examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases, we used the restriction fragment length polymorphism (RFLP) technique to genotype the samples. Results: The current study showed that there were no significant differences between the cases and controls in both variants of rs17817449 and rs9939609. However, there were significant correlations between rs17817449 and cholesterol and between rs9939609 and LDL
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.25.M.Sc.2018.Sa.A (Browse shelf(Opens below)) Not for loan 01010110075750000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.25.M.Sc.2018.Sa.A (Browse shelf(Opens below)) 75750.CD Not for loan 01020110075750000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology

Background: Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity-associated (FTO) gene and obesity in adults and children in different ethnic groups. Objective: In our study, the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and adolescents. Subjects and methods: We examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases, we used the restriction fragment length polymorphism (RFLP) technique to genotype the samples. Results: The current study showed that there were no significant differences between the cases and controls in both variants of rs17817449 and rs9939609. However, there were significant correlations between rs17817449 and cholesterol and between rs9939609 and LDL

Issued also as CD

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