Possible role of lncRNA MEG3, lncRNA MAFG-AS1 on miRNA 147 in pathogenesis of Behcet’s disease / by Shimaa Mahmoud Abobakr Mahmoud ; Supervised by Prof. Dr. Olfat Gamil Shaker, Dr. Mohamed Tharwat Hegazy, Dr. Ayman Mohamed Hany Shehata.

By:

Shimaa Mahmoud Abobakr Mahmoud [preparation.]

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Material type: Text

TextLanguage: English Summary language: English, Arabic Producer: 2024Description: 103 pages : illustrations ; 103 cm. + CDContent type:

text

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Unmediated

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volume

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الدور المحتمل للرنا الطويل الغير مكود MEG3 والرنا الطويل الغير مكود MAFG-AS1 والرنا الصغير 147 في نشوء مرض بهجت [Added title page title]

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612.814

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Dissertation note: Thesis (Ph.D)-Cairo University, 2023. Summary: Background .Behcet disease (BD) is an autoinflammatory disease characterized by a triad of uveitis, oral and genital aphthae, and described to have altered Toll-like receptors (TLR) on macrophages. It is diagnosed clinically due to the unavailability of any pathognomonic test. If left untreated, it can lead to disability, so early diagnosis and proper management are a must to restrain the inflammation. LncRNA MEG3 and lncRNA MAFG-AS1 are regulators of miRNA 147, induced upon TLR stimulation. Our study suggested them to be possible new biomarkers for BD. However, this needs to be investigated in future in vivo and in vitro studies. Subjects and methodology The participants in this study were 100 Egyptian adults who were classified into two groups: fifty BD patients, and fifty age and sex-matched controls. Real- time PCR was used to measure the expression levels of serum LncRNA MEG3, lncRNA MAFG-AS1, and miRNA 147. Results LncRNA MEG3 and lncRNA MAFG-AS1 were significantly downregulated in the serum of our BD patients. While serum miRNA 147 was significantly upregulated in BD patients. Conclusions It can be concluded that lncRNA MEG3, lncRNA MAFG-AS1, and miRNA147 are promising diagnostic markers and therapeutic targets for BD patients.Summary: مرض بهجت هو مرض ذاتي المناعة يتميزبوجود قرح بالفم والأعضاء التناسلية والتهاب بالعين. يوصف بوجود متغيرات TLR علي الخلايا الأكلة الكبيرة. يتم تشخيصه اكلينيكيا لغياب اختبار مميز له. أذا تم تركه دون علاج يؤدى الى اعاقة لذلك سرعة التشخيص والعلاج ضرورة للحد من الإلتهاب . الرنا الطويل الغير مكود MEG3 والرنا الطويل الغير مكود MAFG-AS1 منظمين للرنا الصغير 147 الذى ينتج عن اثارة TLR. دراستنا تقترحهم كوسيلة جديدة لتشخيص مرض بهجت.

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Holdings
Item type	Current library	Home library	Call number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.03.Ph.D.2024.Sh.P (Browse shelf(Opens below))	Not for loan	01010110090290000

Thesis (Ph.D)-Cairo University, 2023.

Bibliography: pages 79-103.

Background .Behcet disease (BD) is an autoinflammatory disease characterized by a triad of uveitis, oral and genital aphthae, and described to have altered Toll-like receptors (TLR) on macrophages. It is diagnosed clinically due to the unavailability of any pathognomonic test. If left untreated, it can lead to disability, so early diagnosis and proper management are a must to restrain the inflammation. LncRNA MEG3 and lncRNA MAFG-AS1 are regulators of miRNA 147, induced upon TLR stimulation. Our study suggested them to be possible new biomarkers for BD. However, this needs to be investigated in future in vivo and in vitro studies.
Subjects and methodology
The participants in this study were 100 Egyptian adults who were classified into two groups: fifty BD patients, and fifty age and sex-matched controls. Real- time PCR was used to measure the expression levels of serum LncRNA MEG3, lncRNA MAFG-AS1, and miRNA 147.
Results
LncRNA MEG3 and lncRNA MAFG-AS1 were significantly downregulated in the serum of our BD patients. While serum miRNA 147 was significantly upregulated in BD patients.
Conclusions
It can be concluded that lncRNA MEG3, lncRNA MAFG-AS1, and miRNA147 are promising diagnostic markers and therapeutic targets for BD patients.

مرض بهجت هو مرض ذاتي المناعة يتميزبوجود قرح بالفم والأعضاء التناسلية والتهاب بالعين. يوصف بوجود متغيرات TLR علي الخلايا الأكلة الكبيرة. يتم تشخيصه اكلينيكيا لغياب اختبار مميز له. أذا تم تركه دون علاج يؤدى الى اعاقة لذلك سرعة التشخيص والعلاج ضرورة للحد من الإلتهاب . الرنا الطويل الغير مكود MEG3 والرنا الطويل الغير مكود MAFG-AS1 منظمين للرنا الصغير 147 الذى ينتج عن اثارة TLR. دراستنا تقترحهم كوسيلة جديدة لتشخيص مرض بهجت.

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