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Synthesis and anticonvulsant evaluation of certain moieties derived from diazaspiroalkanediones / Mai Ibrahim Aboelmagd Ali ; Supervised Mohamed Nabil Aboul-Enein , Kamilia Mahmoud Amin

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mai Ibrahim Aboelmagd Ali , 2017Description: 147 P. ; 25cmOther title:
  • تشييد وتقييم الفاعلية المضادة للتشنجات لبعض الجزيئات المشتقة من ثنائي ازاسبيرو الكان داي اون [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: This work deals with the synthesis of novel structures of: 1-[(2-hydroxyethyl)(aryl)amino]-N-substituted cycloalkanecarboxamides (IXa-l) and 2-[(1-substituted carbamoyl)cycloalkyl)(aryl)amino] ethyl acetates (Xa-l) derived from certain diazaspiroalkanediones. The newly synthesized compounds displayed an anticonvulsant activity using the subcutaneous pentylenetetrazole (scPTZ) and maximal electroshock seizure (MES) tests. The compounds were devoid of neurotoxicity in rotarod test. The most potent compounds in the scPTZ screen were Xh, Xd, Xf, IXj, Xl and Xi. Compound Xf was active as a new anticonvulsant agent in both scPTZ and MES screens. Also, a molecular modeling study was performed for the designed target compounds using Autodock 1.5.6
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2017.Ma.S (Browse shelf(Opens below)) Not for loan 01010110073896000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2017.Ma.S (Browse shelf(Opens below)) 73896.CD Not for loan 01020110073896000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

This work deals with the synthesis of novel structures of: 1-[(2-hydroxyethyl)(aryl)amino]-N-substituted cycloalkanecarboxamides (IXa-l) and 2-[(1-substituted carbamoyl)cycloalkyl)(aryl)amino] ethyl acetates (Xa-l) derived from certain diazaspiroalkanediones. The newly synthesized compounds displayed an anticonvulsant activity using the subcutaneous pentylenetetrazole (scPTZ) and maximal electroshock seizure (MES) tests. The compounds were devoid of neurotoxicity in rotarod test. The most potent compounds in the scPTZ screen were Xh, Xd, Xf, IXj, Xl and Xi. Compound Xf was active as a new anticonvulsant agent in both scPTZ and MES screens. Also, a molecular modeling study was performed for the designed target compounds using Autodock 1.5.6

Issued also as CD

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