Physico chemical studies on dimethyltin (IV) complexes with homopiperazine : Synthesis and equilibrium study / Amira Mohamed Abdelwahab ; Supervised Mohamed Mohamed Shoukry , Mohamed Refaat Shehata

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Inorganic Chemistry

The thesis involves the synthesis and characterization of dimethyltin (IV) complexes with homopiperazine (HPIP). The composition and the structure of the complexes are investigated by elemental analysis, IR, NMR, mass spectra and thermal analysis measurements. The complexes formed are 1 : 1 stoichiometry. Protonation equilibria of the ligands, hydrolysis of dimethyltin(IV) and their complex formation equilibrium constants were determined at different temperatures and in dioxane water solutions of different composition. The thermodynamic parameters, {u2206}H{u00B0}, {u2206}S{u00B0} and {u2206}G{u00B0} of homopiperazine complexes were determined in aqueous solution. The formation of ternary complexes of homopiperazine and dimethyltin(IV) with DNA constituents were investigated. The kinetic and thermodynamic parameters of thermal degradation process have been calculated using coats redfern and horowitz metzger methods. Density functional theory (DFT) calculations have been carried out to investigate the equilibrium geometry of the ligand and DMT - HPIP complex at the B3LYP / 6 - 311G (d) and B3LYP / LANL2DZ level of theory, respectively, using gaussian 09 program. The biological activities were investigated

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