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Impact of augmented renal clearnce on enoxaparin therapy in critically ill pateints / Dina Atteya Mohamed Atteya ; Supervised Hala Ezzat Mohamed Abdelnaeem , Mona Hossam Eldin Abdelhameed , Ahmed Mohamed Ibrahim Hasanin

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Dina Atteya Mohamed Atteya , 2015Description: 58 P. : charts ; 25cmOther title:
  • تأثير زيادة التنقية الكلوية على علاج بالإينوكسبارين في مرضى الحالات الحرجة [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia Summary: Fifty critically ill patients receiving enoxaparin prophylactic dose (40mg/day) were included in the study. Creatinine clearance was measured and patients were divided into two groups: normal kidney function group (group C) and augmented renal clearance group (group A). serum anti-factor Xa was measured at baseline, four hours, 12 hours, and 24 hours. Both groups were compared regarding demographic data, severity scores, kidney function, and anti-factor Xa activity.Results Twenty patients (40%) showed ARC and thirty patients (60%) showed normal kidney function. Creatinine clearance was 214±6 in group A versus 112±11 in group C (P=0.001). Serum anti-factor Xa levels was similar in the two groups after four hours (0.2±0.07 Vs 0.2±0.05, P=1). Serum anti-Xa levels were significantly lower in group A compared to group C at 12 and 24 hours (0.06±0.03 Vs 0.1±0.04, P=0.004), (0.01±0.01 Vs 0.05±0.01, P=0.001) respectively.Conclusion ARC patients showed short activity of enoxaparin. This finding draws the attention towards dose adjustment in this type of patients
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.01.Ph.D.2015.Di.I (Browse shelf(Opens below)) Not for loan 01010110069497000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.01.Ph.D.2015.Di.I (Browse shelf(Opens below)) 69497.CD Not for loan 01020110069497000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia

Fifty critically ill patients receiving enoxaparin prophylactic dose (40mg/day) were included in the study. Creatinine clearance was measured and patients were divided into two groups: normal kidney function group (group C) and augmented renal clearance group (group A). serum anti-factor Xa was measured at baseline, four hours, 12 hours, and 24 hours. Both groups were compared regarding demographic data, severity scores, kidney function, and anti-factor Xa activity.Results Twenty patients (40%) showed ARC and thirty patients (60%) showed normal kidney function. Creatinine clearance was 214±6 in group A versus 112±11 in group C (P=0.001). Serum anti-factor Xa levels was similar in the two groups after four hours (0.2±0.07 Vs 0.2±0.05, P=1). Serum anti-Xa levels were significantly lower in group A compared to group C at 12 and 24 hours (0.06±0.03 Vs 0.1±0.04, P=0.004), (0.01±0.01 Vs 0.05±0.01, P=0.001) respectively.Conclusion ARC patients showed short activity of enoxaparin. This finding draws the attention towards dose adjustment in this type of patients

Issued also as CD

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