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Intracellular uptake and storage of bevacizumab in retinal pigment epithelia / Shereen Hassan M. Aboul Naga ; Supervised Mahmoud M. Soliman , Johann Roider , Tamer Macky

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shereen Hassan Mohamed Aboul Naga , 2015Description: 103 P. : facsimiles ; 25cmOther title:
  • إدخال و تخزين مادة البيفازيزوماب داخل الخلايا الصبغية الطلائية الشبكية [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Ophthalmology Summary: Bevacizumab (Avastin®), an anti-VEGF antibody, is used in the treatment of age related macular degeneration, one of the leading causes of legal blindness in the elderly population in the Western world. It was found, that bevacizumab is taken up and stored in vitro in the porcine retinal pigment epithelial (RPE) cells model. In this study, the uptake and intracellular localization of bevacizumab are investigated via immunofluorescence and Western Blot studies, in order to elucidate the underlying mechanism of degradation and storage and possible relevance in vivo. Ultimately, this study attempts to determine the pathophysiology of RPE and bevacizumab interaction and the related pathways, and in combining the data with clinically relevant questions, a better understanding of the function of RPE cells as well as determining potential side effects of anti-VEGF therapy can be reached
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.24.Ph.D.2015.Sh.I (Browse shelf(Opens below)) Not for loan 01010110067692000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.24.Ph.D.2015.Sh.I (Browse shelf(Opens below)) 67692.CD Not for loan 01020110067692000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Ophthalmology

Bevacizumab (Avastin®), an anti-VEGF antibody, is used in the treatment of age related macular degeneration, one of the leading causes of legal blindness in the elderly population in the Western world. It was found, that bevacizumab is taken up and stored in vitro in the porcine retinal pigment epithelial (RPE) cells model. In this study, the uptake and intracellular localization of bevacizumab are investigated via immunofluorescence and Western Blot studies, in order to elucidate the underlying mechanism of degradation and storage and possible relevance in vivo. Ultimately, this study attempts to determine the pathophysiology of RPE and bevacizumab interaction and the related pathways, and in combining the data with clinically relevant questions, a better understanding of the function of RPE cells as well as determining potential side effects of anti-VEGF therapy can be reached

Issued also as CD

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