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A study of the anti-inflammatory effect of histamine H1 and H4 receptor antagonists on dermatitis in mice / Ahmed Fathi Mohamed Ahmed Kamal Eldin ; Supervised Mohamed T. Abdelaziz , Fatma A. Elbatrawy , Mohammed F. Elyamany

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Fathi Mohamed Ahmed Kamal Eldin , 2015Description: 156 P. : charts , photographs ; 25cmOther title:
  • المضاد للالتهاب فى التهاب الجلد بالفئران H4 و H1 دراسة لتأثير مضادات مستقبلات الهستامين [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: The present study aimed to examine the ability of dexamethasone, cetirizine and JNJ7777120 to alleviate FITC - induced inflammation and oxidative stress. Ears of mice treated with the aforementioned agents 20 minutes before and 4 hours after FITC challenge exhibited amelioration of oxidative stress as manifested by decreased TBARS and NOX contents parallel to increased GSH content and SOD activity. Decreased inflammatory biomarkers as manifested by decreased MPO and EPO activities as well as TNF - Ü content. This was associated with a decrease in plasma IgE level and ear IL - 4 content, in addition to improvement of histopathologic insults, decreased ear thickness and reduced bouts of scratching
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Ah.S (Browse shelf(Opens below)) Not for loan 01010110067639000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Ah.S (Browse shelf(Opens below)) 67639.CD Not for loan 01020110067639000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

The present study aimed to examine the ability of dexamethasone, cetirizine and JNJ7777120 to alleviate FITC - induced inflammation and oxidative stress. Ears of mice treated with the aforementioned agents 20 minutes before and 4 hours after FITC challenge exhibited amelioration of oxidative stress as manifested by decreased TBARS and NOX contents parallel to increased GSH content and SOD activity. Decreased inflammatory biomarkers as manifested by decreased MPO and EPO activities as well as TNF - Ü content. This was associated with a decrease in plasma IgE level and ear IL - 4 content, in addition to improvement of histopathologic insults, decreased ear thickness and reduced bouts of scratching

Issued also as CD

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