header
Local cover image
Local cover image
Image from OpenLibrary

Prognostic impact of CXCR4 and VLA4 expression in acute myeloid leukemia patients / Rania Soliman Hamza Awad ; Supervised Manal Mohamed Wagdi Elmasry , Doha Abdelhamid Mokhtar , Ola Mohamed Reda Khorshid

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rania Soliman Hamza Awad , 2018Description: 217 P. : charts ; 25cmOther title:
  • التأثير التكهنى للتعبير عن (سى إكس سى آر ٤) و ({uئآ٦ؤ}ـى آل إيه ٤) فى مرضى سرطان الدم الميلودى الحاد [Added title page title]
Subject(s): Online resources: Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Introduction: A great number of distinct antigens affect AML prognosis and prediction. Nevertheless, difficulties are still found in performing accurate risk stratification for diagnoses based on immunophenotypic features. Improving the accuracy of prognostic assessment of AML may allow the treatment to be more specific and risk-adapted. Here, we measured CXCR4, VLA-4 and CD200 expressions in leukemic myeloblasts to determine their prognostic implications. Methods: Using multicolor flow cytometry, our studied markers expressions were measured in leukemic myeloblasts in bone marrow aspirates that were obtained from newly diagnosed adult AML patients (n=80). Median values of the studied markers expression divided patients into high and low expressing groups. Results: High VLA-4 expression was associated with gum hyperplasia (p=0.028). FAB (M4, M5) was significantly higher within the high CXCR4 expressing group and nearly significant within the high VLA-4 expressing group (p=0.04 and 0.07 respectively). Among the 75 non-promyelocytic leukemia patients analyzed who received cytarabine + anthracycline-based induction chemotherapy, high VLA-4 expression was associated with longer disease free survival (p=0.005) and progression free survival (p=0.009) and a trend of longer overall survival. High CD200 was associated with longer overall survival (p=0.042) and progression free survival (p=0.044)
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2018.Ra.P (Browse shelf(Opens below)) Not for loan 01010110077879000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2018.Ra.P (Browse shelf(Opens below)) 77879.CD Not for loan 01020110077879000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Introduction: A great number of distinct antigens affect AML prognosis and prediction. Nevertheless, difficulties are still found in performing accurate risk stratification for diagnoses based on immunophenotypic features. Improving the accuracy of prognostic assessment of AML may allow the treatment to be more specific and risk-adapted. Here, we measured CXCR4, VLA-4 and CD200 expressions in leukemic myeloblasts to determine their prognostic implications. Methods: Using multicolor flow cytometry, our studied markers expressions were measured in leukemic myeloblasts in bone marrow aspirates that were obtained from newly diagnosed adult AML patients (n=80). Median values of the studied markers expression divided patients into high and low expressing groups. Results: High VLA-4 expression was associated with gum hyperplasia (p=0.028). FAB (M4, M5) was significantly higher within the high CXCR4 expressing group and nearly significant within the high VLA-4 expressing group (p=0.04 and 0.07 respectively). Among the 75 non-promyelocytic leukemia patients analyzed who received cytarabine + anthracycline-based induction chemotherapy, high VLA-4 expression was associated with longer disease free survival (p=0.005) and progression free survival (p=0.009) and a trend of longer overall survival. High CD200 was associated with longer overall survival (p=0.042) and progression free survival (p=0.044)

Issued also as CD

There are no comments on this title.

to post a comment.

Click on an image to view it in the image viewer

Local cover image