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A pharmaceutical study on modified drug delivery systems containing a short acting drug / Michael Magdy Farag Abdelmalak ; Supervised Soad A. Yehia , Nevine S. Abdelmalak

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Michael Magdy Farag Abdelmalak , 2017Description: 185 P. : charts , facsimiles ; 25cmOther title:
  • دراسة صيدلية عن نظم توصيل معدلة تحتوى على عقار قصير المفعول [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Zaleplon is a hypnotic drug indicated for the short term management of insomnia for sleep induction. Also it has shown efficacy in treatment of middle of night insomnia without hangover effects. Zaleplon undergoes an extensive hepatic first pass metabolism leaving only 30% systemically available. Its elimination half-life is I hour. ZLP belongs to BCS class II with poor solubility and high permeability. Despite being rapidly absorbed after oral adminstration, the poor aqueous solubility of ZLP limits its dissolution rate and delays its onset of action. The best achieved formula of chaper I FM5 showed optimum mucoadhesion strength (1507.12±62.238 mcg/cm²) and controlled release profile (Q₃hr= 29.06%±0.73% and Q₁₂hr= 87.24%±1.71%) with desirability {u2243} 0.7
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2017.Mi.P (Browse shelf(Opens below)) Not for loan 01010110075267000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2017.Mi.P (Browse shelf(Opens below)) 75267.CD Not for loan 01020110075267000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Zaleplon is a hypnotic drug indicated for the short term management of insomnia for sleep induction. Also it has shown efficacy in treatment of middle of night insomnia without hangover effects. Zaleplon undergoes an extensive hepatic first pass metabolism leaving only 30% systemically available. Its elimination half-life is I hour. ZLP belongs to BCS class II with poor solubility and high permeability. Despite being rapidly absorbed after oral adminstration, the poor aqueous solubility of ZLP limits its dissolution rate and delays its onset of action. The best achieved formula of chaper I FM5 showed optimum mucoadhesion strength (1507.12±62.238 mcg/cm²) and controlled release profile (Q₃hr= 29.06%±0.73% and Q₁₂hr= 87.24%±1.71%) with desirability {u2243} 0.7

Issued also as CD

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