Exploring the effect of conformational variability on the biophysical identity of HCV NS5B polymerase / Abdo Abdo Abdellah Mohamed Elfiky ; Supervised Wael M. Elshemey , Wissam A. Gawad , Omar S. Desoky
Material type:
TextLanguage: English Publication details: Cairo : Abdo Abdo Abdellah Mohamed Elfiky , 2013Description: 153 Leaves : charts ; 25cmOther title: - إستكشاف تأثير التغير البنائى على الشخصية البيوفيزيائية لبوليماريز فيروس سى الكبدى الوبائى [Added title page title]
- Issued also as CD
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Thesis
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قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.12.04.Ph.D.2013.Ab.E (Browse shelf(Opens below)) | Not for loan | 01010110061672000 | ||
CD - Rom
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مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.12.04.Ph.D.2013.Ab.E (Browse shelf(Opens below)) | 61672.CD | Not for loan | 01020110061672000 |
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics
PS{u2160}-7977, IDX-{u2160}84 and R7{u2160}28 are hepatitis C virus (HCV) non-structural 5b (NS5B) RNA dependent RNA polymerase (RdRp) nucleotide inhibitors (NIs) that are currently in phase {u2161} ({u2160}DX-{u2160}84 and R7128) and {u2162} (PS{u2160}-7977) clinical trials. The activated form of these Direct Acting aAntiviral (DAA) drugs acts on NS5B RdRp through a coordination bond with the two Mg+² present at the active site of the polymerase
Issued also as CD
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