Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry

Epidemiological and basic science evidence suggest a possible shared pathophysiology between type 2 diabetes mellitus (T2DM) and alzheimer's dementia (AD). Compare between type 2 diabetic, non diabetic AD and control regarding cognitive functions and metabolic abnormalities, assess cerebral blood flow (CBF) and correlate it with the severity of both DM and AD. Three groups were included. group (Gr) I: 20 patients with AD + DM, Gr II: 26 patients with AD only and were matched with Gr III: including 20 normal control (NC). The following were done for all patients: A battery of neuropsychological tests, laboratory tests (lipid profile, serum uric acid, fasting blood glucose, post prandial blood glucose, glycosated hemoglobin, insulin level, insulin resistance and serum insulin like growth factor 1) then assessment of CBF using extracranial carotid duplex (ECD) and single photon emission computerized tomography SPECT

Issued also as CD