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Synthesis and anti tumor evaluation of Heterocyclic compounds synthesized from Ý-diketone and active methylene derivatives / Marwa Soliman Gaman Salama ; Supervised Rafat Milad Mohareb

By: Contributor(s): Material type: TextLanguage: English Publication details: Cairo : Marwa Soliman Gaman Salama , 2016Description: 120 P. ; 25cmOther title:
  • تحضير و قياس مضادات الأورام لمركبات غير متجانسة الحلقة محضرة من مشتقات البيتا ثنائى الكيتون و الميثيلين النشطة [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry Summary: In this work the reaction of O-phenylenediamine (1) with diethylmalonate (2) in an oil bath at 120 {u00B0}C gave ethyl 2- (1H-benzo [d] imidazol-2-yl) acetate (3). Compound 3 was used in many acyclic and heterocyclic reactions. The latter products underwent a series of heterocyclization reactions to yield pyrazole, thiophene, pyridine and coumarin derivatives. The antitumor evaluations of the newly synthesized products against three cancer cell lines were measured
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Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.M.Sc.2016.Ma.S (Browse shelf(Opens below)) Not for loan 01010110070999000
CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.M.Sc.2016.Ma.S (Browse shelf(Opens below)) 70999.CD Not for loan 01020110070999000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

In this work the reaction of O-phenylenediamine (1) with diethylmalonate (2) in an oil bath at 120 {u00B0}C gave ethyl 2- (1H-benzo [d] imidazol-2-yl) acetate (3). Compound 3 was used in many acyclic and heterocyclic reactions. The latter products underwent a series of heterocyclization reactions to yield pyrazole, thiophene, pyridine and coumarin derivatives. The antitumor evaluations of the newly synthesized products against three cancer cell lines were measured

Issued also as CD

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