Clinical significance of minimal residual disease in peripheral blood at day 8 induction in childhood precursor- B acute lymphoblastic leukemia /
Seham Mohamed Mahmoud
Clinical significance of minimal residual disease in peripheral blood at day 8 induction in childhood precursor- B acute lymphoblastic leukemia / الأهمية الاكلينيكية للمرض المتبقى الأدنى بخلايا الدم عند اليوم الثامن من مرحلة الحث للعلاج الكيميائى فى الأطفال الذين يعانون من اللوكيميا الليمفاوية الحادة-ذات الخلية (ب) المبكرة Seham Mohamed Mahmoud ; Supervised Iman Abdelmokhles Sidhom , Magda Mahmoud Assem , Iman Aly Attia - Cairo : Seham Mohamed Mahmoud , 2014 - 183 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology
Background: Minimal residual disease (MRD) in childhood acute lymphoblastic leukemia (ALL) during the early stages of therapy is statistically significant indicator of outcome. Aim: To study the prognostic significance of MRD by flow-cytometry in peripheral blood (PB) on day-8 induction in pediatric B-precursor ALL. Patients and Methods: This is study included 140 newly diagnosed B-precursor ALL pediatric patients treated at the Childrens Cancer Hospital- Egypt during the period between mid of March 2010 and end of September 2011. ALL patients received adopted protocol of St. Jude Childrens Research Hospital total study XV for low or standard/high risk ALL. Results: The 3-year relapse-free survival (RFS) and event-free survival (EFS) were 87±3.5% and 82±3.7% respectively. Median follow up was 34.9 months (range 2442). MRD PB day-8 <1% was encountered in 78% of patients. Patients with day-8 MRD <1% had 3-year RFS of 90.6±3.4% compared to 73±10.7% for day-8 MRD 1% (P=0.042). Prognostic factors had statistically significant impact on RFS by univariate analysis were patient risk, favorable triple trisomies, and MRD PB day-8. By multivariate analysis, patient risk was the only independent factor affecting RFS
Acute lymphoblastic leukemia Favorable trisomies Minimal residual disease
Clinical significance of minimal residual disease in peripheral blood at day 8 induction in childhood precursor- B acute lymphoblastic leukemia / الأهمية الاكلينيكية للمرض المتبقى الأدنى بخلايا الدم عند اليوم الثامن من مرحلة الحث للعلاج الكيميائى فى الأطفال الذين يعانون من اللوكيميا الليمفاوية الحادة-ذات الخلية (ب) المبكرة Seham Mohamed Mahmoud ; Supervised Iman Abdelmokhles Sidhom , Magda Mahmoud Assem , Iman Aly Attia - Cairo : Seham Mohamed Mahmoud , 2014 - 183 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology
Background: Minimal residual disease (MRD) in childhood acute lymphoblastic leukemia (ALL) during the early stages of therapy is statistically significant indicator of outcome. Aim: To study the prognostic significance of MRD by flow-cytometry in peripheral blood (PB) on day-8 induction in pediatric B-precursor ALL. Patients and Methods: This is study included 140 newly diagnosed B-precursor ALL pediatric patients treated at the Childrens Cancer Hospital- Egypt during the period between mid of March 2010 and end of September 2011. ALL patients received adopted protocol of St. Jude Childrens Research Hospital total study XV for low or standard/high risk ALL. Results: The 3-year relapse-free survival (RFS) and event-free survival (EFS) were 87±3.5% and 82±3.7% respectively. Median follow up was 34.9 months (range 2442). MRD PB day-8 <1% was encountered in 78% of patients. Patients with day-8 MRD <1% had 3-year RFS of 90.6±3.4% compared to 73±10.7% for day-8 MRD 1% (P=0.042). Prognostic factors had statistically significant impact on RFS by univariate analysis were patient risk, favorable triple trisomies, and MRD PB day-8. By multivariate analysis, patient risk was the only independent factor affecting RFS
Acute lymphoblastic leukemia Favorable trisomies Minimal residual disease