Synthesis of some new mono and bis-heterocyclic compounds with anticipated biological activity from laboratory available starting materials /
Salwa Magdy Ahmed Eldaly
Synthesis of some new mono and bis-heterocyclic compounds with anticipated biological activity from laboratory available starting materials / تشييد بعض المركبات احادية و ثنائية الحلقة غير المتجانسة الجديدة ذات نشاط بيولوجى متوقع من بادئات متوافرة معمليا Salwa Magdy Ahmed Eldaly ; Supervised Fathy Mohamed Abdelrazek - Cairo : Salwa Magdy Ahmed Eldaly , 2019 - 264 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry
Part I: Synthesis of Mono - Heterocyclic Compounds: N-(4-cinnamoylphenyl)-2-cyanoacetamide 2 underwent Knvenagel condensation with different derivatives of salicyaldehyde 5a-c and 8a-d to afford the respective chromene derivatives. Compound 2 reacted with malononitrile and ethyl cyanoacetate under Gewald reaction conditions to obtain the corresponding 2-aminothiophene derivatives. Enaminone derivative of compound 2 underwent reaction with each of hydrazine hydrate, guanidine and cyanoguanidine to afford diaminopyrazole 23 and diaminopyrimidines 24a,b respectively, also it reacted with different 3,5-diamino-4-arylazo-1H-pyrazoles 17a-e to afford the respective dipyrazolo[1,5-a]pyrimidines 25a-f. Part II: Synthesis of Bis - Heterocyclic Compounds: N,N'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-cyanoacetamide) 53 underwent Knvenagel condensation with different derivatives of salicyaldehyde 5a-c affording bis chromene derivatives. Compound 53 reacted with different Ü-halocompounds to afford the corresponding bisthiazole derivatives 61a-c. In addition to compound 53 reacted with different arylhydrazo derivatives of ethyl cyanoacetate and malononitrile to afford the bispyridazine derivatives 65a-d and 67a-d. Moreover, bisaminopyrazole 70 reacted with compounds 71a-c, 73a-f and 75a-d to afford bispyrazolo[1,5-a]pyrimidines. Anticancer investigation and Molecular docking were performed for some newly synthesized compounds
Bis-2-aminothiophene Chromene di-aminopyrazole
Synthesis of some new mono and bis-heterocyclic compounds with anticipated biological activity from laboratory available starting materials / تشييد بعض المركبات احادية و ثنائية الحلقة غير المتجانسة الجديدة ذات نشاط بيولوجى متوقع من بادئات متوافرة معمليا Salwa Magdy Ahmed Eldaly ; Supervised Fathy Mohamed Abdelrazek - Cairo : Salwa Magdy Ahmed Eldaly , 2019 - 264 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry
Part I: Synthesis of Mono - Heterocyclic Compounds: N-(4-cinnamoylphenyl)-2-cyanoacetamide 2 underwent Knvenagel condensation with different derivatives of salicyaldehyde 5a-c and 8a-d to afford the respective chromene derivatives. Compound 2 reacted with malononitrile and ethyl cyanoacetate under Gewald reaction conditions to obtain the corresponding 2-aminothiophene derivatives. Enaminone derivative of compound 2 underwent reaction with each of hydrazine hydrate, guanidine and cyanoguanidine to afford diaminopyrazole 23 and diaminopyrimidines 24a,b respectively, also it reacted with different 3,5-diamino-4-arylazo-1H-pyrazoles 17a-e to afford the respective dipyrazolo[1,5-a]pyrimidines 25a-f. Part II: Synthesis of Bis - Heterocyclic Compounds: N,N'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-cyanoacetamide) 53 underwent Knvenagel condensation with different derivatives of salicyaldehyde 5a-c affording bis chromene derivatives. Compound 53 reacted with different Ü-halocompounds to afford the corresponding bisthiazole derivatives 61a-c. In addition to compound 53 reacted with different arylhydrazo derivatives of ethyl cyanoacetate and malononitrile to afford the bispyridazine derivatives 65a-d and 67a-d. Moreover, bisaminopyrazole 70 reacted with compounds 71a-c, 73a-f and 75a-d to afford bispyrazolo[1,5-a]pyrimidines. Anticancer investigation and Molecular docking were performed for some newly synthesized compounds
Bis-2-aminothiophene Chromene di-aminopyrazole