Synthesis of some new mono and bis-heterocyclic compounds with anticipated biological activity from laboratory available starting materials / (Record no. 73176)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02836cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032337.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190730s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.10.Ph.D.2019.Sa.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Salwa Magdy Ahmed Eldaly |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis of some new mono and bis-heterocyclic compounds with anticipated biological activity from laboratory available starting materials / |
| Statement of responsibility, etc. | Salwa Magdy Ahmed Eldaly ; Supervised Fathy Mohamed Abdelrazek |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تشييد بعض المركبات احادية و ثنائية الحلقة غير المتجانسة الجديدة ذات نشاط بيولوجى متوقع من بادئات متوافرة معمليا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Salwa Magdy Ahmed Eldaly , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 264 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Part I: Synthesis of Mono - Heterocyclic Compounds: N-(4-cinnamoylphenyl)-2-cyanoacetamide 2 underwent Kn{u04E7}venagel condensation with different derivatives of salicyaldehyde 5a-c and 8a-d to afford the respective chromene derivatives. Compound 2 reacted with malononitrile and ethyl cyanoacetate under Gewald reaction conditions to obtain the corresponding 2-aminothiophene derivatives. Enaminone derivative of compound 2 underwent reaction with each of hydrazine hydrate, guanidine and cyanoguanidine to afford di{u2013}aminopyrazole 23 and di{u2013}aminopyrimidines 24a,b respectively, also it reacted with different 3,5-diamino-4-arylazo-1H-pyrazoles 17a-e to afford the respective di{u2013}pyrazolo[1,5-a]pyrimidines 25a-f. Part II: Synthesis of Bis - Heterocyclic Compounds: N,N'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-cyanoacetamide) 53 underwent Kn{u04E7}venagel condensation with different derivatives of salicyaldehyde 5a-c affording bis chromene derivatives. Compound 53 reacted with different Ü-halocompounds to afford the corresponding bis{u2013}thiazole derivatives 61a-c. In addition to compound 53 reacted with different arylhydrazo derivatives of ethyl cyanoacetate and malononitrile to afford the bis{u2013}pyridazine derivatives 65a-d and 67a-d. Moreover, bis{u2013}aminopyrazole 70 reacted with compounds 71a-c, 73a-f and 75a-d to afford bis{u2013}pyrazolo[1,5-a]pyrimidines. Anticancer investigation and Molecular docking were performed for some newly synthesized compounds |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bis-2-aminothiophene |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chromene |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | di-aminopyrazole |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fathy Mohamed Abdelrazek , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.10.Ph.D.2019.Sa.S | 01010110078884000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.10.Ph.D.2019.Sa.S | 01020110078884000 | 22.09.2023 | CD - Rom | 78884.CD |