A study of the effects of certain agents in lung injury induced by a chemotherapeutic drug in rats / (Record no. 171717)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 05985namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250512105856.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250427s2024 ua a|||fr|m|| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.9 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.9 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.09.Ph.D.2024.Em.S. |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Eman AbdAlhameid Hussein Mahmoud saad, |
| Preparation | preparation. |
| 245 12 - TITLE STATEMENT | |
| Title | A study of the effects of certain agents in lung injury induced by a chemotherapeutic drug in rats / |
| Statement of responsibility, etc. | By Eman AbdAlhameid Hussein Mahmoud saad; Under the supervision of Dr. Sanaa A. Kenawy, Dr. Hala M. Fawzy, Dr. Enas A. Abd El-Haleim, Dr. Gehan S. Georgy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة تأثير بعض المواد فى الإصابة الرئوية المحدثة بدواء كيماوي في الجرذان / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 134 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 115-134. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Purpose: Methotrexate is an antimetabolite drug used to treat various diseases. Unfortunately, <br/>about 30% of patients had to stop it due to its serious side effects such as lung fibrosis. The <br/>current work was conducted to examine the probable shielding influence of cinnamic acid as <br/>well as methylene blue against lung fibrosis induced by methotrexate, compared to pirfenidone. <br/>Methods: Rats were pre-treated with oral administration of cinnamic acid (50 mg/kg/day) for 14 <br/>days, as well as methylene blue (8 mg/kg/day) whereas methotrexate (14 mg/kg) was orally <br/>given on the 5th and 12th days of the experiment. Pirfenidone (50 mg/kg/day) was used as a <br/>standard drug. At the end of the experiment, oxidative parameters (malondialdehyde, <br/>myeloperoxidase, nitric oxide, and total glutathione) and inflammatory mediators (tumor <br/>necrosis factor-α and interleukin-8), as well as transforming growth factor-β and collagen <br/>content, as fibrosis indicators, were measured in lung tissue. <br/>Results: The present results revealed that cinnamic acid or methylene blue, as pirfenidone, <br/>effectively prevented the methotrexate-induced overt histopathological damage. This was <br/>associated with parallel improvements in oxidative, inflammatory, and fibrotic parameters <br/>measured. The outcomes of cinnamic acid administration were more or less the same as those of <br/>pirfenidone. <br/>Conclusion: Pre-treatment with cinnamic acid as well as methylene blue protects against <br/>methotrexate-induced fibrosis, making it a promising prophylactic adjuvant therapy to <br/>methotrexate and protecting against its possible induction of lung fibrosis. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | الغرض: الميثوتريكسات هو دواء مضاد للايض يستخدم لعلاج الأمراض المختلفة. لسوء الحظ ، اضطر حوالي 30% من المرضى إلى إيقافه بسبب آثاره الجانبية الخطيرة مثل تليف الرئة. تم إجراء العمل الحالي لفحص تأثير الردع المحتمل لحمض سيناميك وكذلك أزرق الميثيلين ضد تليف الرئة الناجم عن الميثوتريكسات ، مقارنة بالبيرفينيدون.<br/>الطريقة: تمت معالجة الفئران مسبقا بالإعطاء الفموي لحمض سيناميك (50 مجم / كجم / يوم) لمدة 14 يوما ، بالإضافة إلى الميثيلين الأزرق (8 مجم / كجم / يوم) بينما تم إعطاء الميثوتريكسات (14 مجم / كجم) عن طريق الفم في اليومين 5 و 12 من التجربة. تم استخدام بيرفينيدون (50 مجم / كجم / يوم) كدواء قياسي.<br/>في نهاية التجربة، تم اكتشاف عوامل الأكسدة (مالونديالدهيد، ميلوبيروكسيديز، أكسيد النيتريك، والجلوتاثيون الكلي) ووسطاء الالتهابات (عامل نخر الورم-ألفا والإنترلوكين-8)، بالإضافة إلى عامل النمو المحول- بيتا ومحتوى الكولاجين، كمؤشرات التليف، تم قياسها في أنسجة الرئة.<br/>النتائج: كشفت النتائج الحالية أن حمض سيناميك أو أزرق الميثيلين ، مثل بيرفينيدون ، منع بشكل فعال الضرر النسيجي المرضي العلني الناجم عن الميثوتريكسات. ارتبط هذا بتحسينات موازية في العوامل المؤكسدة والالتهابية والليفية التي تم قياسها. كانت نتائج إعطاء حمض سيناميك مماثلة إلى حد ما لنتائج بيرفينيدون.<br/>الخلاصة: المعالجة المسبقة بحمض سيناميك وكذلك أزرق الميثيلين تحمي من التليف الناجم عن الميثوتريكسات ، مما يجعله علاجا مساعدا وقائيا واعدا للميثوتريكسات ويحمي من أثره المحتمل لتليف الرئة. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | toxicology |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | methotrexate |
| -- | cinnamic acid |
| -- | methylene blue |
| -- | pirfenidone |
| -- | lung fibrosis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa A. Kenawy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala M. Fawzy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Enas A. Abd El-Haleim |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gehan S. Georgy |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Sanaa A. Kenawy |
| -- | Hala M. Fawzy |
| -- | Enas A. Abd El-Haleim |
| -- | Gehan S. Georgy |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of pharmacology & toxicology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Nourhan |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 27.04.2025 | 90855 | Cai01.08.09.Ph.D.2024.Em.S. | 01010110090855000 | 27.04.2025 | 27.04.2025 | Thesis |