MARC details
| 000 -LEADER |
|---|
| fixed length control field |
05369namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - أخر تعامل مع التسجيلة |
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| control field |
20251103105803.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
251021s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloguing agency |
EG-GICUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GICUC |
| Modifying agency |
EG-GICUC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract |
eng |
| -- |
ara |
| 049 ## - Acquisition Source |
|---|
| Acquisition Source |
Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
546 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) |
|---|
| Classification number |
546 |
| Edition number |
21 |
| 097 ## - Degree |
|---|
| Degree |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Local Call Number |
Cai01.12.09.M.Sc.2024.Mo.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Authority record control number or standard number |
Mohamed Ahmed Mohamed Abdel Wahab, |
| Preparation |
preparation. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Synthesis and characterization of modified metal based nano materials and their applications / |
| Statement of responsibility, etc. |
by Mohamed Ahmed Mohamed Abdel Wahab ; Supervisors Prof. Dr. Mohamed A. Zaye, Dr. Ayman S. Eliwa. |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
التأثير العلاجي للميلاتونين مع / أو الخلايا الجذعية الوسيطة المشتقة من النسيج الدهني على السمية الكبدية الكلوية المستحثة بالدوكسوروبيسين –في جرذان ويستار |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
2024. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
116 pages : |
| Other physical details |
illustrations ; |
| Dimensions |
25 cm. + |
| Accompanying material |
CD. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Source |
rda content |
| 337 ## - MEDIA TYPE |
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| Media type term |
Unmediated |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
volume |
| Source |
rdacarrier |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Bibliography: pages 97-112. |
| 520 #3 - SUMMARY, ETC. |
|---|
| Summary, etc. |
Doxorubicin (DOX), is highly potent against cancer, but it is limited due to its severe side effects, including hepatotoxicity and renal toxicity. This toxicity is caused by oxidative stress, resulting in biochemical, histological, and genetic abnormalities. The antioxidant activity of Melatonin (MEL) and the regenerative properties of Adipose-derived mesenchymal stem cells (ADMSCs) show a promising strategy against DOX-induced toxicity. This study investigated the therapeutic effects of MEL & ADMSCs against DOX-induced toxicity. The research aimed to find whether the antioxidant properties of MEL, the regenerative capabilities, and the anti-inflammatory effect of ADMSCs could synergistically alleviate the adverse effects of DOX. The study included 2 main groups: a negative control group and a DOX group receiving 6 doses of DOX to induce organ toxicity. Subsequently, rats from both groups were subdivided to receive treatments of saline, MEL, ADMSCs, or a combination of them. Rats were euthanized, then blood and tissue samples were collected. The analysis included the evaluation of histopathological changes, oxidative stress biomarkers, gene expression profiles, and DNA damage. DOX induces oxidative stress, inflammation, and genotoxicity in livers and kidneys while reducing antioxidant enzyme activity. MEL and/or ADMSCs treatments effectively mitigate these effects, suggesting the protective mechanisms involved in apoptosis pathways, evidenced by changes in p53 and Bcl-2 expression levels, as well as assessment of double-stranded breaks using the neutral comet assay, and also improvement of the inflammatory markers IL-6 & IL-10 evidenced by the histopathological changes. MEL and ADMSCs counteract the adverse effects caused by DOX, potentially enhancing chemotherapy safety. The synergistic benefits of combination therapy in improving chemotherapy tolerability allow further investigation in preclinical models to optimize treatment strategies and support efficacy before clinical application. |
| 520 #3 - SUMMARY, ETC. |
|---|
| Summary, etc. |
الهدف من هذه الأطروحة هو تخليق قاعدة شييف كرا بطة عضيوية صيلبة طويلة )رابط( في بنية .MOF دراسات فيزيائية كيميائية على را بطة قاعدة شيف المصنعة باستخدام FT-IR و XRD و 1HNMR وقييا الطيف الكتلي والتحلييل الحراري. أي لضييييا، تخليق أطر عضييييويية معيدنيية يدييدة، Co-MOF من خلال تفاعل أيونات الكوبلت (II) وقاعدة شيف تحت ظروف التفاعل المائي الحراري التقليدية. تم اسييتخدام العديد من أدوات التوصيييف لإلقاء الضييوء على بنية وسييلو MOFs المصيينعة (Co-MOF) مثل FTIR، حيود الأشييييعة السييييينية للمسييييحوق، قياسييييات التحليل الوزني الحراري (TGA)، تحليل (BET) Brunauer-Emmett-Teller، المجهر الإلكتروني الماسيح نبلا للى ن مع تقنييات قييا .EDX تم التحقيق في MOFs المصيييينعية (Co-MOF) كمحفزات كهربيائيية فعيالية للعديد من التطبيقات البيئية مثل تقسيم الماء والأكسدة الكهربائية للميثانول. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Issues CD |
Issues also as CD. |
| 546 ## - LANGUAGE NOTE |
|---|
| Text Language |
Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Inorganic Chemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
الكيمياء غير العضوية |
| 653 #1 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Metal-organic framework (MOF) |
| -- |
Electrochemical oxidation |
| -- |
Water splitting |
| -- |
Fuel cell, |
| -- |
X-ray diffraction (XRD) |
| -- |
scanning electron microscope (SEM) |
| -- |
energy dispersive X-ray (EDX) |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed A. Zaye |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ayman S. Eliwa. |
| Relator term |
thesis advisor. |
| 900 ## - Thesis Information |
|---|
| Grant date |
01-01-2025 |
| Supervisory body |
Mohamed A. Zaye |
| -- |
Ayman S. Eliwa |
| Universities |
Cairo University |
| Faculties |
Faculty of Science |
| Department |
Department of Chemistry |
| 905 ## - Cataloger and Reviser Names |
|---|
| Cataloger Name |
Shimaa |
| Reviser Names |
Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
| Edition |
21 |
| Suppress in OPAC |
No |