Improvement of depressive-like behavior through inhibiting neuroinflammation in rats / (Record no. 175526)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05655namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251104210941.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251104s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 612.015 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 612.015 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.01.M.Sc.2025.Me.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Merna Adel Labib Shehata, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Improvement of depressive-like behavior through inhibiting neuroinflammation in rats / |
| Statement of responsibility, etc. | by Merna Adel Labib Shehata ; Supervised Prof. Dr. Noha Ahmed Mahmoud El-Boghdady, Prof. Nevine Fathy Abdel Karim, Dr. Reham Mohamed Essam. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحسين سلوك الاكتئاب من خلال تثبيط الالتهاب العصبي في الجرذان |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 91 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 72-91 |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Major depressive disorder (MDD) is considered the major cause of suicide worldwide. As previous studies revealed that neuroinflammation is a significant factor in the etiology of MDD, so this study was proposed to unravel the possible anti-depressant effect of Empagliflozin (EMPA) through targeting miRNA-134 (miR-134)/brain-derived neurotrophic factor (BDNF) and liver kinase B1 (LKB1)/adenosine 5'-monophosphate-activated protein kinase (AMPK)/silent information regulator 1 (SIRT1) axes in ovariectomized (OVX) female rats. Rats were assigned randomly to four groups: Sham operation (SO), OVX, OVX+ EMPA (10 mg/kg/day, p.o.) and OVX+ EMPA+ Dorsomorphin (DORSO), an AMPK inhibitor (25 μg/day/rat, i.v). Drugs were administered for 28 days after two weeks of surgery. EMPA debilitated OVX-induced depressive-like behavior by mitigating the immobility time in tail suspension test and forced swimming test. Moreover, EMPA curtailed OVX-induced alterations in serum estradiol, hippocampal serotonin, miR-134 expression, as well as BDNF. Besides, EMPA dwindled OVX-induced changes in hippocampal p-LKB1/LKB1, p-AMPK/AMPK, SIRT1 and inflammatory markers (NF-ƙB, nuclear factor-kappaB; IL-1β, interleukin-1 beta; IL-6, interleukin-6 and TNF-α, tumor necrosis factor alpha). Additionally, the EMPA-treated group exhibited a marked improvement in the histopathology of different brain regions. However, DORSO co-administration reversed most of EMPA’s beneficial effects. The current study displayed the modulatory role of EMPA on miR-134/BDNF and LKB1/AMPK/SIRT1 axes thus offering a partial explanation of its antidepressant efficacy and proposing EMPA as a novel therapeutic avenue for MDD in females. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | يعتبر الاضطراب الاكتئابي الشديد (MDD) السبب الرئيسي للانتحار في جميع أنحاء العالم. كما كشفت الدراسات السابقة أن الالتهاب العصبي هو عامل مهم في مسببات MDD، لذلك هدفت هذه الدراسة إلى كشف التأثير المحتمل المضاد للاكتئاب لـ EMPA من خلال استهداف miR-134/ BDNF و LKB1/AMPK / SIRT1 في إناث الجرذان بعد عملية استئصال المبيض (OVX) . تم توزيع الجرذان عشوائيًا على أربع مجموعات: عملية وهمية (SO)، OVX، OVX + EMPA (10 ملغ/كغم/يوم، عن طريق الفم) وOVX + EMPA + Dorsomorphin (DORSO) (25 ميكروغرام/يوم/فأر، عن طريق الوريد). تم إعطاء الأدوية لمدة 28 يومًا بعد أسبوعين من الجراحة. قام EMPA بإضعاف السلوك الشبيه بالاكتئاب الناتج عن طريق تقليل وقت عدم الحركة في اختبار تعليق الذيل واختبار السباحة القسري. علاوة على ذلك، حسن EMPA التغييرات التي يسببها OVX لاستراديول، والسيروتونين، وmiR-134، وكذلك BDNF. قلل EMPA أيضًا من التغييرات التي يسببها OVX في p-LKB1 / LKB1، p-AMPK / AMPK، SIRT1 وعلامات الالتهابات(NF-κB و IL-1β وIL-6 وTNF-α). بالإضافة إلى ذلك، أظهرت المجموعة المعالجة بـ EMPA تحسنًا ملحوظًا في تشريح الأنسجة لمناطق المخ المختلفة. ومع ذلك، فقد عكس DORSO معظم التأثيرات المفيدة لـ EMPA. عرضت الدراسة الحالية الدور الفعال لـ EMPA على محاور miR-134/BDNF وLKB1/AMPK/SIRT1 وبالتالي قدمت تفسيرًا جزئيًا لفعالية الEMPA كمضاد للاكتئاب وتقترح EMPA كوسيلة علاجية واعدة لـ MDD |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biochemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الكيمياء الحيوية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | BDNF |
| -- | Dorsomorphin |
| -- | Empagliflozin |
| -- | LKB1/AMPK/SIRT1 pathway |
| -- | Major depressive disorder |
| -- | miRNA-134 |
| -- | Ovariectomy |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Ahmed Mahmoud El-Boghdady |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nevine Fathy Abdel Karim |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reham Mohamed |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Noha Ahmed Mahmoud El-Boghdady |
| -- | Nevine Fathy Abdel Karim |
| -- | Reham Mohamed |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Demonstrator of Biochemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 04.11.2025 | 92368 | Cai01.08.01.M.Sc.2025.Me.I | 01010110092368000 | 04.11.2025 | 04.11.2025 | Thesis |