Synthesis of biologically active Heterocyclic compounds from cyanomethylene reagents and β-diketones / (Record no. 175731)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03812namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251111103838.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251110s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 547.59 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 547.59 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.10.Ph.D.2025.Ma.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Marwa Shokry Ibrahim Bayoumy, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis of biologically active Heterocyclic compounds from cyanomethylene reagents and β-diketones / |
| Statement of responsibility, etc. | by Marwa Shokry Ibrahim Bayoumy ; Supervisor: Prof. Dr. Rafat Milade Mohareb, Prof. Dr. Rafaat Ibrahim Naseem. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير مركبات حلقيه غير متجانسة نشطه بيولوجيا من كواشف السيانوميثلين و البيتا ثنائى الكيتونات |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 220 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 201-220. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | This work involves the synthesis of novel heterocyclic compounds across the three sections of the original study.This study explores the synthesis of xanthene derivatives 3a-c through a two-component reaction between cyclohexane-1,3-dione and aromatic aldehydes. These intermediates were further transformed via heterocyclization using elemental sulfur and phenylisothiocyanate to produce fused thiazole derivatives. Alternatively, treating the xanthenes with sulfur alone resulted in fused thiophene derivatives.Multicomponent reactions involving 3a-c, aromatic aldehydes, and either furfural or benzaldehyde led to the formation of xanthene derivatives.Biological evaluations revealed that several of the synthesized compounds demonstrated potent anti-proliferative activity. The most promising candidates were further tested for tyrosine kinase inhibition, exhibiting significant inhibitory effects. Additionally, morphological assessments were conducted on A549 cell lines to investigate the impact of the two most active compounds. This research's results highlight these compounds' potential and provide a strong foundation for further investigations. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | هدفت الدراسة الحالية إلى استخدام سلسلة من مركبات الكربونيل غير المشبعة (البيتا ثنائى الكيتونات) في تصنيع مشتقات الزانثينات، البيريدين، البيران، الثيوفين، الثيازول، واستخداماتها في تصنيع الحلقات غير المتجانسة. تم تقييم السمية الخلوية للمنتج المحضر حديثا مقابل ستة خطوط خلايا سرطانية مختارة وهي (A549، H460، HT-29، MKN-45، U87MG) وفحوصات التثبيط ضد خمسة كينازات التيروزين. تم التأكد من تركيب مركبات المنتج بناء على البيانات التحليلية والطيفية. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Heterocyclic compounds |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | المركبات الحلقية غير المتجانسة |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Multicomponent |
| -- | xanthenes |
| -- | thiazole |
| -- | thiophene |
| -- | fused derivatives |
| -- | anti-proliferative evaluations |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rafat Milade Mohareb |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rafaat Ibrahim Naseem |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Rafat Milade Mohareb |
| -- | Rafaat Ibrahim Naseem |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 10.11.2025 | 92443 | Cai01.12.10.Ph.D.2025.Ma.S | 01010110092443000 | 10.11.2025 | 10.11.2025 | Thesis |