MARC details
| 000 -LEADER |
|---|
| fixed length control field |
04547namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GICUC |
| 005 - أخر تعامل مع التسجيلة |
|---|
| control field |
20251214140655.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
251214s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloguing agency |
EG-GICUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GICUC |
| Modifying agency |
EG-GICUC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract |
eng |
| -- |
ara |
| 049 ## - Acquisition Source |
|---|
| Acquisition Source |
Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
547 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) |
|---|
| Classification number |
547 |
| Edition number |
21 |
| 097 ## - Degree |
|---|
| Degree |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Local Call Number |
Cai01.12.10.M.Sc.2025.Mo.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Authority record control number or standard number |
Mohamed Saber Mohamed, |
| Preparation |
preparation. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Synthesis of some novel compounds containing nitrogen and/or sulfur elements via michael and/or hantzsch reactions / |
| Statement of responsibility, etc. |
by Mohamed Saber Mohamed ; Supervisors: Prof. Dr. Ismail Abdelshafy Abdelhamid, Prof. Dr. Amr Mohamed Abdelmoniem, Dr. Moaz Mohamed Abdou. |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تحضير بعض المركبات الجديدة التى تحتوي على عناصر النتروجين و/أو الكبريت من خلال تفاعلات مايكل و/أو هانتزش |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
2025. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
124 pages : |
| Other physical details |
illustrations ; |
| Dimensions |
25 cm. + |
| Accompanying material |
CD. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Source |
rda content |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
Unmediated |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
volume |
| Source |
rdacarrier |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Bibliography: pages 112-118. |
| 520 #3 - SUMMARY, ETC. |
|---|
| Summary, etc. |
Introduction: 2.5% of adults worldwide suffer from hyperthyroidism, which is associated <br/>with osteoporosis, heart disease, and increased mortality. Aim: The current study evaluates <br/>the preventive and therapeutic effect of Ovothiol-A on Thyroxine-induced hyperthyroidism <br/>in rats. Methods: Experimental animals were split into two categories: protective and curative. <br/>Each group was further separated into three subgroups (6 per group): control, hyperthyroidism <br/>(HT), and Ovothiol-A (250 mg/kg). Thyroxine hormone (600 mg/kg) is administered orally <br/>to rats to induce HT. Results: Ovothiol-A supplementation resulted in significant decreases <br/>in organs weight index, triiodothyronine (T3), thyroxine (T4), aspartate aminotransferase <br/>(AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, urea, uric <br/>acid, creatine kinase (CK-MB), lactate dehydrogenase (LDH), fasting blood sugar (FBS), <br/>malondialdehyde (MDA), and nitric oxide (NO) levels, fibrosis, and tumor necrosis factor <br/>alpha (TNF-α) while increasing in body weight, Thyroid-stimulating hormone (TSH), lipid <br/>profile, total protein (TP), serum albumin, total cholesterol (TC), serum triglycerides (TG), <br/>low density lipoprotein cholesterol (LDL-C), high density lipoproteins cholesterol (HDL-C), <br/>glutathione <br/>reduced (GSH), catalase (CAT), glutathione-S-transferase (GST). <br/>Histopathological investigation revealed significant improvement in the thyroid gland, liver, <br/>kidney, and heart tissues, significantly reducing collagen deposition. The electrocardiogram <br/>(ECG) revealed an improvement in ST segment and heart rhythm. <br/>Conclusion: Ovothiol-A exhibited protective and therapeutic effects against <br/>hyperthyroidism in rats. Ovothiol-A exhibits antithyroid activity by stimulating the <br/>antioxidant system, reducing inflammation, and restoring thyroid hormone levels. |
| 520 #3 - SUMMARY, ETC. |
|---|
| Summary, etc. |
اشتملت الدراسة علي تصنيع سلسلة جديدة من المركبات الحلقية غير المتجانسة التي تحتوي على 4و5- ثنائي فينيل-1H-إيميدازول، وبنزوثيازول، و1H-فينانثرو[9و10-d]إيميدازول، وتتراهيدروكرومين، وإيمينوبيران، و4H-بيران هجينة تعتمد على 2-(4-(1-فينيل-1H-بيرازول-3-يل)فينوكسي)-N-أريل أسيتاميدات عبر روابط ذرات غير متجانسة من الكربون-الكربون و باستخدام عمليات التكثيف الحلقي متعدد المكونات وعبر تفاعلات مايكل. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Issues CD |
Issues also as CD. |
| 546 ## - LANGUAGE NOTE |
|---|
| Text Language |
Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Organic Chemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
كيمياء عضوية |
| 653 #1 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
hyperthyroidism |
| -- |
Ovothiol-A |
| -- |
oxidative stress |
| -- |
thyroid gland |
| -- |
liver dysfunction |
| -- |
kidney |
| -- |
heart |
| -- |
histopathology |
| -- |
fibrosis |
| -- |
بيرازول |
| -- |
ديميدون |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ismail Abdelshafy Abdelhamid |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Amr Mohamed Abdelmoniem |
| Relator term |
thesis advisor. |
| 900 ## - Thesis Information |
|---|
| Grant date |
01-01-2025 |
| Supervisory body |
Ismail Abdelshafy Abdelhamid |
| -- |
Amr Mohamed Abdelmoniem |
| -- |
Moaz Mohamed Abdou |
| Universities |
Cairo University |
| Faculties |
Faculty of Science |
| Department |
Department of Chemistry |
| 905 ## - Cataloger and Reviser Names |
|---|
| Cataloger Name |
Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
| Edition |
21 |
| Suppress in OPAC |
No |