Thesis (M.Sc)-Cairo University, 2025.

Bibliography: pages 112-118.

Introduction: 2.5% of adults worldwide suffer from hyperthyroidism, which is associated
with osteoporosis, heart disease, and increased mortality. Aim: The current study evaluates
the preventive and therapeutic effect of Ovothiol-A on Thyroxine-induced hyperthyroidism
in rats. Methods: Experimental animals were split into two categories: protective and curative.
Each group was further separated into three subgroups (6 per group): control, hyperthyroidism
(HT), and Ovothiol-A (250 mg/kg). Thyroxine hormone (600 mg/kg) is administered orally
to rats to induce HT. Results: Ovothiol-A supplementation resulted in significant decreases
in organs weight index, triiodothyronine (T3), thyroxine (T4), aspartate aminotransferase
(AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, urea, uric
acid, creatine kinase (CK-MB), lactate dehydrogenase (LDH), fasting blood sugar (FBS),
malondialdehyde (MDA), and nitric oxide (NO) levels, fibrosis, and tumor necrosis factor
alpha (TNF-α) while increasing in body weight, Thyroid-stimulating hormone (TSH), lipid
profile, total protein (TP), serum albumin, total cholesterol (TC), serum triglycerides (TG),
low density lipoprotein cholesterol (LDL-C), high density lipoproteins cholesterol (HDL-C),
glutathione
reduced (GSH), catalase (CAT), glutathione-S-transferase (GST).
Histopathological investigation revealed significant improvement in the thyroid gland, liver,
kidney, and heart tissues, significantly reducing collagen deposition. The electrocardiogram
(ECG) revealed an improvement in ST segment and heart rhythm.
Conclusion: Ovothiol-A exhibited protective and therapeutic effects against
hyperthyroidism in rats. Ovothiol-A exhibits antithyroid activity by stimulating the
antioxidant system, reducing inflammation, and restoring thyroid hormone levels.

اشتملت الدراسة علي تصنيع سلسلة جديدة من المركبات الحلقية غير المتجانسة التي تحتوي على 4و5- ثنائي فينيل-1H-إيميدازول، وبنزوثيازول، و1H-فينانثرو[9و10-d]إيميدازول، وتتراهيدروكرومين، وإيمينوبيران، و4H-بيران هجينة تعتمد على 2-(4-(1-فينيل-1H-بيرازول-3-يل)فينوكسي)-N-أريل أسيتاميدات عبر روابط ذرات غير متجانسة من الكربون-الكربون و باستخدام عمليات التكثيف الحلقي متعدد المكونات وعبر تفاعلات مايكل.

Issues also as CD.

Text in English and abstract in Arabic & English.