Synthesis, docking simulation, biological activities, and molecular studies of some novel unsaturated compounds containing nitrogen and/or sulfur elements / (رقم التسجيلة. 179361)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 05404namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260423101108.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260410s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 572 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 572 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.02.M.Sc.2025.Em.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Eman Hatem Mohamed Shoukry, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis, docking simulation, biological activities, and molecular studies of some novel unsaturated compounds containing nitrogen and/or sulfur elements / |
| Statement of responsibility, etc. | by Eman Hatem Mohamed Shoukry ; Supervisor Prof. Dr. Ismail Abdelshafy Abdelhamid, Dr .Nada Sabry Ibraheem Abd Elhady, Dr.Marwa Mohamed Mohamed Ahmed Sharaky. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير وتنميط جزيئي وأنشطة بيولوجية ودراسات جزيئية لبعض المركبات الجديدة غير المشبعة التي تحتوي على عناصر النيتروجين و/أو الكبريت |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 78 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 70-76. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Six novel chalcones were synthesized, and their structures were confirmed using various <br/>spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening <br/>against nine cancer and two normal cell lines. Compound 7a showed the highest impact <br/>against colorectal carcinoma (HCT116) and cervical cancer (HeLa) with IC50 values of <br/>4.6±0.03 and 5.5±0.1 μg/mL, respectively, compared to doxorubicin (4.8±0.4 and 5.7±0.4 <br/>μg/mL, respectively). ELISA assay revealed that the apoptotic proteins (P53, Bax, <br/>caspases-3, -8, and -9) and the oxidative marker (Malondialdehyde (MDA)) were <br/>significantly activated in 7a treated HCT116 and HeLa cells. However, the anti-metastatic <br/>markers (Matrix metalloproteinase 2 (MMP2) and Matrix metalloproteinase-9 (MMP9)), <br/>anti-apoptotic Bcl2, antioxidant Glutathione reductase (GR), and anti-inflammatory <br/>(interleukin (IL)-6, and IL- 1β) were inhibited in HCT116 and HeLa cells treated with 7a. <br/>Flow-cytometric analysis of the cell cycle revealed that the percentage of cells in S and <br/>G2/M phases in 7a treated HCT116 cells was increased. After 24 h of treatment, Hela-<br/>treated cells had a slightly higher proportion of G0/G1 cells. Comet assay demonstrated <br/>that compound 7a caused DNA damage with a percentage of 26.22 ± 1.1 % in HCT116 <br/>compared to the untreated cells (6.18±0.88 %). Theoretical molecular modeling against <br/>P53 cancer mutant Y220C and Bcl2 showed binding energies of -22.7 and -23.3 kcal/mol, <br/>respectively, which confirmed our ELISA results. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | لقد تم تحضير سته شالكونات جديدة، وتم التأكد منها باستخدام الوسائل الطيفية المختلفة. لقد تم اختبار كل مركب مُصنَّع للتأكد من سميته للخلايا ضد العديد من خطوط الخلايا السرطانية، وأظهر المركب 7aافضل النتائج ضد خلايا سرطان القولون والمستقيم و خلايا عنق الرحم السرطانية . وفقًا لفحص ELISA (المقايسة الامتصاصية المناعية للانزيم المرتبط ) تم ملاحظة زياده نشاط MDA , p53, Bax, caspases-3, -8, -9 بشكل كبير وتثبيط MMP2, MMP9, Bcl2, GSH, IL-6, IL-1β فى خلايا سرطان القولون والمستقيم و خلايا عنق الرحم السرطانية المعالجة بـ 7a. وفقًا لتحليل التدفق الخلوي لدورة الخلية لقد زادت نسبة الخلايا فى مرحلة S و G2/M في خلايا سرطان القولون والمستقيم المعالجة ب 7a بينما زادت نسبة الخلايا زيادة طفيفة فى مرحلة G0/G1 فى خلايا عنق الرحم السرطانية المعالجة ب .7a أظهر اختبار المذنب ان مركب 7a تسبب فى تلف الحمض النووى فى خلايا سرطان القولون و المستقيم. لقد تم التحقق من صحة بيانات الاليزا الخاصة بنا من خلال النمذجة الجزيئية النظرية ضد طفرات سرطان P53 Y220C وBcl2. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biochemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الكيمياء الحيوية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chalcones |
| -- | Intrinsic and extrinsic apoptosis |
| -- | anti-inflammatory |
| -- | anti- metastatic |
| -- | molecular docking |
| -- | شالكونات |
| -- | الموت المبرمج للخلية داخليا و خارجيا |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ismail Abdelshafy Abdelhamid |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nada Sabry Ibraheem Abd Elhady |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Mohamed Mohamed Ahmed Sharaky |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Ismail Abdelshafy Abdelhamid |
| -- | Nada Sabry Ibraheem Abd Elhady |
| -- | Marwa Mohamed Mohamed Ahmed Sharaky |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 10.04.2026 | 93719 | Cai01.12.02.M.Sc.2025.Em.S | 01010110093719000 | 10.04.2026 | 10.04.2026 | Thesis |