Study of In vitro inactivation of rabies virus by hydrogen peroxide / (Record no. 55599)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02619cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031443.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160319s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.06.M.Sc.2015.As.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Ahmed Abdelghaffar |
| 245 10 - TITLE STATEMENT | |
| Title | Study of In vitro inactivation of rabies virus by hydrogen peroxide / |
| Statement of responsibility, etc. | Asmaa Ahmed Abdelghaffar ;Supervised Magdy Ali Amin , Amal Emad Eldin , Abeer A. Elhalim Boseila |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة تثبيط فيروس داء الكلب باستخدام بيروكيد الهدروجين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Asmaa Ahmed Abdelghaffar , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 105 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Development of safe and protective vaccines against infectious pathogens remains a challenge. Inactivation of rabies virus is a critical step in the production of vaccines and other research reagents. Beta-propiolactone (ÝPL); the currently used inactivating agent for rabies virus is expensive and proved to be carcinogenic in animals. This study aimed to investigate the ability of hydrogen peroxide (H₂O₂) to irreversibly inactivate rabies virus without affecting its antigenicity and immunogenicity in pursuit of finding safe, effective and inexpensive alternative inactivating agents. H₂O₂ 3% rapidly inactivated a Vero cell adapted fixed rabies virus strain designated as FRV/K within two hours of exposure without affecting antigenicity or immunogenicity. No residual infectious virus was detected and the H₂O₂- inactivated vaccine proved to be safe and effective when compared with the same virus harvest inactivated with the classical inactivating agent (ÝPL). Mice immunized with H₂O₂-inactivated rabies virus produced sufficient level of antibodies and were protected when challenged with lethal CVS virus. These findings reinforce the idea that H₂O₂ can replace ÝPL as inactivating agent for rabies virus to reduce time and cost of inactivation process |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hydrogen Peroxide |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Inactivation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Rabies |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abeer A. Elhalim Boseila , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amal Emad Eldin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Ali Amin , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.06.M.Sc.2015.As.S | 01010110068296000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.06.M.Sc.2015.As.S | 01020110068296000 | 22.09.2023 | CD - Rom | 68296.CD |