Phytochemical and biological studies of soil fungi on hepatic diseases / (Record no. 74730)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03309cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032424.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191024s2019 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.07.M.Sc.2019.Ab.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Abdelhalim Adel Yousof Elgahamy |
| 245 10 - TITLE STATEMENT | |
| Title | Phytochemical and biological studies of soil fungi on hepatic diseases / |
| Statement of responsibility, etc. | Abdelhalim Adel Yousof Elgahamy ; Supervised Ahlam Mahmoud Elfishawy , Nagwa Elsayed A. Awad |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسات فيتوكيميائية و بيولوجية لفطريات التربة علي أمراض الكبد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Abdelhalim Adel Yousof Elgahamy , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 203 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study is concerned with two antagonistic soil fungi trichoderma koningii (T. koningii) and Gliocladium roseum (G. roseum); in order to find out new drugs used in the treatment of liver diseases. The liquid culture filtrates of both fungi were subjected to successive extraction using different polar solvents. The phytochemical investigation of the resulted extracts of the two fungi revealed the presence of glycosides{u2215}carbohydrates, sterol{u2215}triterpenes, tannins and nitrogenous metabolites. Only T. koningii produces coumarins and anthraquinones. GC{u2215}MS analysis was carried out for the prepared saponifiable and non-saponifiable matters of pet. ether extracts of both fungal filtrates. Both fungi proved promising activity as biological control agents according to the antagonistic activity. The obtained extracts from culture filtrates of both fungi were evaluated against different microbial strains. The ethyl acetate and the dichloromethane extracts from both fungal filtrates exhibited the highest activity while pet. ether and butanol extracts showed the lowest activity. Also, all extracts were evaluated against three different human cancer cell lines (HepG2, HCT116 and MCF7). The ethyl acetate extract of T. koningii and dichoromethane extract of G.roseum were the most active agents against HepG2 with IC50 19 og{u2215}ml and 18.8 og{u2215}ml respectively. But in case of HCT116; the ethyl acetate extract of T.koningii and pet. ether of G.roseum were the most active agents with IC50 29.5 og{u2215}ml and 73.3 og{u2215}ml respectively. While pet. ether extract of G.roseum and dichoromethane extract of T. koningii were the most active agents against MCF7 with IC50 90.1 og{u2215}ml and 75.2 og{u2215}ml respectively. Both of ethyl acetate extract of T.koningii and dichoromethane extract of G.roseum were evaluated in the treatment of thioacetamide (TAA) induced liver toxicity. Only ethyl acetate extract of T.koningii has proved the ability to treat TAA induced liver disease |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antagonistic study |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gliocladium roseum |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Trichoderma koningii |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahlam Mahmoud Elfishawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nagwa Elsayed A. Awad , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.07.M.Sc.2019.Ab.P | 01010110079586000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.07.M.Sc.2019.Ab.P | 01020110079586000 | 22.09.2023 | CD - Rom | 79586.CD |