Potential therapeutic efficacy of certain natural products against colorectal cancer cells / (رقم التسجيلة. 83557)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03145cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032900.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211213s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.02.Ph.D.2021.Es.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Esraa Aly Zeen Elabdeen Khalil |
| 245 10 - TITLE STATEMENT | |
| Title | Potential therapeutic efficacy of certain natural products against colorectal cancer cells / |
| Statement of responsibility, etc. | Esraa Aly Zeen Elabdeen Khalil ; Supervised Wafaa Ahmed Abdullah , Saad Elguendy , Amany Abdelhameed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير العلاجى المحتمل لبعض النباتات الطبيعيه لعلاج سرطان القولون والمستقيم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Esraa Aly Zeen Elabdeen Khalil , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 122 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Colorectal cancer is the third most common cancer, but it is the second most deadly cancer worldwide. In Egypt, Colorectal cancer is Egypt's seventh most prevalent cancer, accounting for 3.47 percent of male cancers and 3% of female cancers. Jasonia Montana is one of the most prevalent therapeutic herbs. The bio medicinal action of Jasonia montana is due to a variety of active compounds that combine to form the complex impact of the plant. Quercetin is one of the important flavonoids that exert anti{u2010}proliferative effects on cancer cells mediated by various mechanisms of action including alterations in gene expression of oncogenes, tumor suppressor genes. MiRNAs are short, non-protein-coding RNAs {u223C}22 nucleotides in length that are known to alter gene expression at a post-transciptional level. Here, we investigated the potential efficacy of jasonia Montana to trigger colon cancer cells toward differentiation. In this study we fulfilled miRNAs& their targeted genes related to differentiation pathways such as NOTCH, PI3K/AKT & pluroipotancy gene SOX2 in both CACOO2&HCT116 colon cell lines and then evaluate stem cell marker CD44& differentiation marker CK20 to ensure the efficacy of jasonia Montana toward differentiation. Using syber green RT-qPCR , both miR-21& miR-10B were shown to be significantly downregulated While their targeted gene PTEN (which included in PI3K/AKT pathway) shown to be significantly upregulated . On the other hand, miR-34a was significantly up regulated &its targeted gene NOTCH1 was down regulated,miR-145 was upregulated while its targeted gene SOX2 was down regulated. Finally, CD44 as stem cell marker was downregulated while CK20 as differentiation marker was upregulated. In conclusion, jasonia Montana may be used as |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Colorectal cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Jasonia montana |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | miRNAs |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amany Abdelhameed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Saad Elguendy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wafaa Ahmed Abdullah , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.02.Ph.D.2021.Es.P | 01010110084984000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.02.Ph.D.2021.Es.P | 01020110084984000 | 22.09.2023 | CD - Rom | 84984.CD |