Clinicopathological studies on some novel renal biomarkers in cats / by Ghada Mohamed Mohamed Ahmed Khalil ; Supervised Prof. Dr. Safaa Y. S. Ahmed, Prof. Dr. Shaymaa I. Salem, Prof. Dr. Khaled M. A. Mahran, Dr. Mohamed E. Ali.
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TextLanguage: English Summary language: English, Arabic Producer: 2024Description: 98 pages : illustrations ; 25 cm. + CDContent type: - text
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- volume
- دراسات باثولوجية إكلينيكو لبعض دلالات الكلى الحيوية الحديثة في القطط [Added title page title]
- 636.8
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Thesis
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قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.10.05.Ph.D.2024.Gh.C (Browse shelf(Opens below)) | Not for loan | 01010110091687000 |
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| Cai01.10.05.Ph.D.2022.Ta.C. Comparative evaluation of camel and sheep wharton jelly mscs therapy in induced chronic kidney disease model in dogs / | Cai01.10.05.Ph.D.2024.Di.E Effect of camel milk whey and rivastigmine nanoparticles on induced alzheimer’s like disease in rats / | Cai01.10.05.Ph.D.2024.Fa.C Clinicopathological study on the application of zinc oxide nanoparticles in treatment of streptococcus parauberis infection in nile tilapia / | Cai01.10.05.Ph.D.2024.Gh.C Clinicopathological studies on some novel renal biomarkers in cats / | Cai01.10.06.M.Sc.1995.El.P Pesticide Residues in Poultry Meat / | Cai01.10.06.M.Sc.1995.Ha.S Studies For Detection Of Antibacterial Residues In Meat / | Cai01.10.06.M.Sc.1996.Kh.P Public Health Aspects of Canned Meat / |
Thesis (Ph.D)-Cairo University, 2024.
Bibliography: pages 74-97.
Renal diseases are common disorders of felines, considered a leading death
cause, and exhibit a diagnostic challenge due to a shortage of early damage markers.
The traditional biomarkers [e.g., serum creatinine (sCr) and blood urea nitrogen (BUN)]
have low diagnostic sensitivity; thus, acute cases progress to chronic. This study aimed
to clarify the clinicopathological, ultrasonographic, and pathological findings of cats
affected with renal diseases, and the performance of novel renal biomarkers [symmetric
dimethyl arginine (SDMA), kidney injury molecule-1 (KIM-1), Tamm-Horsfall protein
(THP), and N-acetyl-β-D-glucosaminidase (NAG)] against the traditional ones.
Furthermore, assessing the novel biomarker‟s role in the follow-up of treated cases. 86
cats were allocated into 4 groups depending on clinical signs, physical examination, sCr
concentration, and urine specific gravity (USG) as follows: I. Control negative group
(15 apparently healthy cats), II. Control positive group (22 renal diseased cats), III. Pre-
azotemic group (31 cats), and IV. Diseased and treated group (18 treated cats). Blood
and spot urine samples were collected from all groups. Blood samples for
hematological, biochemical, arterial blood gas (ABG) analysis, as well as, SDMA, and
KIM-1 concentrations. Spot urine samples for routine urinalysis, some biochemical
parameters, NAG activity, and THP concentration. Groups II and III showed microcytic
hypochromic anemia and significant leukopenia, significant increases in serum
concentrations of SDMA, and KIM-1, and activity of urinary NAG; meanwhile, they
showed a significant decrease in urinary THP concentration. Group IV after treatment
revealed an improvement of all measured parameters except urinary THP concentration.
In conclusion, the current study results found out that SDMA, KIM-1, and NAG could
serve as efficient biomarkers of early renal injury detection and treatment follow-up.
تعتبر أمراض الكلى من أكثر المشكلات الطبية شيوعًا في القطط والتي تسبب خلل فسيولوجي وأيضي. العديد من الأسباب الفسيولوجية المرضية قد تتسبب في إحداثها من بينها الإصابة الحادة للكلي بالتلف والذي بدوره يؤدي إلى إنحدار سريع في وظائف الكلى وقد ينتهي بفشل مزمن في وظائف الكلى. يعنبر القط الحيوان الأكثر إصابة ووفاة من أمراض الكلى المزمنة من أي حيوان آخر خاصة القطط الكبيرة في السن بنسبة حدوث 80 %.
الدلالات الحيوية هي جزيئات حيوية، غالبًا ما تكون بروتينات، تتأرجح (زيادة أو نقصان) نتيجة التغيرات المرضية. بدأ عصر جديد في مجال طب وأمراض الكلى مع ظهور الدلالات الحيوية الجديدة الخاصة بتلف الكلى، كما أنها طورت أولوية بحثية ترتبط بتحسين التشخيص والمتابعة والتكهن وصنع القرارات والأدوات الجديدة الخاصة بأمراض الكلى.
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Text in English and abstract in Arabic & English.
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