Biochemical studies on food fortification with some vitamins and minerals for anemia treatment / by Rania Ahmed Salamma Mahgoub ; Supervisors Dr. Abdel Kader Moursy Abdel-Samad, Dr.Mohamed Abdel-Moneam Naguib, Dr.Mahmoud Abdel-Haleim Mahmoud, Dr. Hanna Hussein El-Sayed.
Material type:
TextLanguage: English Summary language: English, Arabic Producer: 2024Description: 178 pages : illustrations ; 25 cm. + CDContent type: - text
- Unmediated
- volume
- دراسات كيميائية حيوية على تزويد الغذاء ببعض الفيتامينات والمعادن لعلاج الانيمياء [Added title page title]
- 572
- Issues also as CD.
| Item type | Current library | Home library | Call number | Status | Barcode | |
|---|---|---|---|---|---|---|
Thesis
|
قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.07.04.Ph.D.2024.Ra.B (Browse shelf(Opens below)) | Not for loan | 01010110092547000 |
Browsing المكتبة المركزبة الجديدة - جامعة القاهرة shelves Close shelf browser (Hides shelf browser)
Thesis (Ph.D)-Cairo University, 2024.
Bibliography: pages 156-178.
Iron deficiency anemia (IDA) represents a critical global health concern. This
investigation involves the characterization and evaluation of several
nanoparticle formulations—iron oxide magnetic nanoparticles (IONPs), zinc
oxide nanoparticles (ZnO-NPs), magnesium oxide nanoparticles (MgO-NPs),
and iron folate nanoparticles—as potential treatments for IDA. For the in vivo
study, 110 Sprague-Dawley rats (both female and male) were divided into
seven groups: a normal group, anemic rats, and four groups treated with
various iron formulations. IDA was induced in the rats using an iron-deficient
diet, followed by feeding with different iron compounds until their hemoglobin
levels reached 12 g/dl. The rats were then placed on a normal diet for two
weeks. Biological and hematological parameters were monitored throughout
the treatment. Results indicated that all treated groups showed positive
outcomes, achieving normal values. Notably, iron folate nanoparticles
demonstrated superior bioavailability, with female rats showing 244.23% HRE
ratio/day and 19.89% RBV HRE ratio/day, and male rats showing 155.02%
HRE ratio/day and 16.63% RBV HRE ratio/day, outperforming other treatments.
Histopathological analysis revealed persistent liver tissue damage in anemic
rats treated with FeSO4 and IONPs, though FeMgO-NPs and iron folate
nanoparticles showed better results. The spleen appeared normal across all
repleted groups. These findings suggest that IONPs can enhance iron
bioavailability for IDA treatment, though their efficacy is improved when
combined with other metals to maximize benefits and reduce side effects
يمثل فقر الدم الناجم عن نقص الحديد مشكلة صحية عالمية بالغة الاهمية. يتضمن هذا البحث توصيف وتقييم بيولوجي للعديد من تركيبات جزيئات أكسيد الحديد النانوية في علاجات فقر الدم الناجم عن نقص الحديد. اشارت النتائج الى ان جميع المجموعات المعالجة حققت قيما طبيعية. والجدير بالذكر ان جزيئات حمض الفوليك النانوية أظهرت توافرا حيويا متفوقا. تشير هذه النتائج الى ان جزيئات أكسيد الحديد النانوية يمكن ان تعزز التوافر الحيوي للحديد لعلاج فقر الدم الناجم عن نقص الحديد وتتحسن فعاليتها عند دمجها مع معادن نانوية وحمض الفوليك كفيتامين لتحقيق اقصى قدر من الفوائد وتقليل الاثار الجانبية.
Issues also as CD.
Text in English and abstract in Arabic & English.
There are no comments on this title.