Design, synthesis and biological evaluation of novel 2 - oxopyridine and 2- iminopyridine derivatives as potential anticancer and phosphodiesterase inhibitors / Mohamed Assem Omar Abdelfattah ; Supervised Ashraf H. Abadi , Dalal A. Abouelella
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TextLanguage: English Publication details: Cairo : Mohamed Assem Omar Abdelfattah , 2009Description: 119 Leaves : charts ; 30cmOther title: - تصميم وتشييد وتقييم بيولوجى لبعض مشتقات الاكسوبيريدين والامينوبيريدين كمضادات للسرطان ومثبطات لانزيم فوسفودايستراز [Added title page title]
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قاعة الثقاقات الاجنبية - الدور الثالث | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.34.M.Sc.2009.Mo.D (Browse shelf(Opens below)) | C.2 | Not for loan | 01010110060233000 | |
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قاعة الثقاقات الاجنبية - الدور الثالث | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.34.M.Sc.2009.Mo.D (Browse shelf(Opens below)) | Not for loan | 01010110052215000 |
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Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Milrinone is a cyanopyridone derivative that has been introduced for the treatment of CHF . Its mechanism of action involves inhibition of PDE3, leading to elevation of cAMP increasing the entry of Ca++ ions into the cardiac tissues and hence increasing the contractility of the cardiac muscle . On the other hand recent studies showed that PDE3 and other PDEs are over - expressed in malignant tumors and the inhibition of such PDEs and consequent high levels of cAMP or cGMP or both may be associated with anticancer and apoptotic activities
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