Design synthesis and biological evaluation of novel tetrahydro - Ý - carboline derivatives as phosphodiesterase 5 inhibitors / Mohamed Saleh Mohamed Ali ; Supervised Ashraf H. Abadi
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TextLanguage: English Publication details: Cairo : Mohamed Saleh Mohamed Ali , 2009Description: 94 P. : facsimiles ; 30cmOther title: - تصميم وتشييد بعض مشتقات البيتاكربولين وتقييمها بيولوجيا كمثبطات لإنزيم الفسفودايستراز5 [Added title page title]
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Thesis
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قاعة الثقاقات الاجنبية - الدور الثالث | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.34.M.Sc.2009.Mo.D (Browse shelf(Opens below)) | Not for loan | 01010110053006000 |
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Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Science in Organic Chemistry
PDE5 inhibitors is a large class of compounds that are primarily used to treat erectile dysfunction (MED) as well as having other medical applications . Tadalafil is one of the most potent members among this class despite its efficacy in treatment of MED it only exhibits a modest selectivity of 5 - folds for PDE - 5 compareed PDE - 11 which may be involved in sperm formation motility and\ or other homonal functions
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