Association of platelet endothelial cell adhesion molecule - 1 (PECAM -1) gene polymorphisms with coronary artery disease / Heba Mohamed Amer ; Supervised Laila Abdelrahman Hegazy , Hassan Mohamed Khalid , Asmaa Ahmed Abdelaal

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Heba Mohamed Amer

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TextLanguage: English Publication details: Cairo : Heba Mohamed Amer , 2014Description: 130 P. : charts , facsimiles ; 25cmOther title:

بمرض شرايين القلب التاجية (PECAM-1) ارتباط التغير الشكلى لجينات جزيئات المركب الملتصق بالخلايا البطانية و الصفائح الدموية [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Platelet endothelial cell adhesion molecule -1 (PECAM - 1) plays a key role in the transendothelial migration of circulating leukocytes, a characteristic event in vascular inflammation leading to atherosclerotic plaque formation. The aim of the present study was to determine the role of PECAM - 1 in the development of coronary artery disease (CAD). Two single nucleotide polymorphisms (SNPs) of PECAM - 1 gene: C + 373G (Leu125Val) at exon 3 and G + 1688A (Ser563Asn) at exon 8 were analyzed in 50 angiographically documented ( > 70% stenosis) Egyptian patients with CAD and 40 age- and sex-matched controls using a polymerase chain reaction -restriction fragment length polymorphism PCR - RFLP strategy

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.He.A (Browse shelf(Opens below))		Not for loan	01010110064261000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.He.A (Browse shelf(Opens below))	64261.CD	Not for loan	01020110064261000

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Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Platelet endothelial cell adhesion molecule -1 (PECAM - 1) plays a key role in the transendothelial migration of circulating leukocytes, a characteristic event in vascular inflammation leading to atherosclerotic plaque formation. The aim of the present study was to determine the role of PECAM - 1 in the development of coronary artery disease (CAD). Two single nucleotide polymorphisms (SNPs) of PECAM - 1 gene: C + 373G (Leu125Val) at exon 3 and G + 1688A (Ser563Asn) at exon 8 were analyzed in 50 angiographically documented ( > 70% stenosis) Egyptian patients with CAD and 40 age- and sex-matched controls using a polymerase chain reaction -restriction fragment length polymorphism PCR - RFLP strategy

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