Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics

In this study the golden standard test for detection of HPV was considered PCR-ISH tissue. We found PCR-ISH tissue was positive in 16 cases (53.33%) and 14 cases (46.6%) were negative. The age of studied group ranged from (20-50) years with mean and standard deviation (SD) 32.77+7.99 while the duration of marriage in 29 cases (0.5-30) years, as one was divorced, with mean and SD 12.95+8.26. Comparing the result of pap smear, histopathology, colposcopy and PCR swap in diagnosis of HPV with the golden standard test ISH PCR tissue, the sensitivity were 87.5%, 100%, 62.5% and 56,2% respectively but the specificity were 78.6%, 42.9%, 28.6% and 100% respectively This study aimed to evaluate the different methods of diagnosis of cervical HPV infection in Egyptian females by cytology, histopathology, colposcopy and HPV genotyping.This study included 30 patient with either abnormal pap smears prior to colposcopic examination (10 cases) and abnormal T Z zone on colposcopic examination (20 cases).We considered Pap smear result suggestive of the presence of HPV infection when we found (ASUS, LSIL, HSIL, koliocytic atypia)

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