Evaluation of the role of keratinocytes apoptosis and impaired cell to cell adhesion in vitiligo: Immunohistochemical expression of MART1, P53 and E-cadherin / Mohammed Hussien Mostafa Elmahdy ; Supervised Naiema A.M. Marie , Samia Mohammed Gabal , Mostafa Samy Salem

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Mohammed Hussien Mostafa Elmahdy

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TextLanguage: English Publication details: Cairo : Mohammed Hussien Mostafa Elmahdy , 2015Description: 125 P. : charts , facsimiles ; 25cmOther title:

(E-cadherin) و (P53)(MART) تقييم دور موت الخلايا الكيراتينية المبرمج و اضطراب اتصال الخلايا ببعضها في البهاق: التعبير المناعي لكل من [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Background: Vitiligo is an acquired, hypomelanotic skin disorder characterized by circumscribed depigmented macules. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes. Some studies supported the hypothesis that keratinocytes apoptosis and impaired intercellular adhesion may play a role in the pathogenesis of vitiligo. Objectives: To assess the role of keratinocytes apoptosis and impaired intercellular adhesion in the pathogenesis of vitiligo through the studying of immunohistochemical presence and distribution of MART1, P53 and E-cadherin in the epidermis Results: Regarding to immunostaining of both E-cadherin & P53, there was a highly significant difference between lesional biopsies of cases and control groups. Also there was a highly significant difference between lesional biopsies of cases and perilesional and non lesional biopsies of the same cases. No significant difference was noted regarding the disease stability. Conclusion: vitiligo is not a disease confined to melanocytes. Keratinocytes apoptosis and impaired cell to cell adhesion may play prominent role in the pathogenesis of the disease.

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.27.Ph.D.2015.Mo.E (Browse shelf(Opens below))		Not for loan	01010110067087000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.27.Ph.D.2015.Mo.E (Browse shelf(Opens below))	67087.CD	Not for loan	01020110067087000

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Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology

Background: Vitiligo is an acquired, hypomelanotic skin disorder characterized by circumscribed depigmented macules. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes. Some studies supported the hypothesis that keratinocytes apoptosis and impaired intercellular adhesion may play a role in the pathogenesis of vitiligo. Objectives: To assess the role of keratinocytes apoptosis and impaired intercellular adhesion in the pathogenesis of vitiligo through the studying of immunohistochemical presence and distribution of MART1, P53 and E-cadherin in the epidermis Results: Regarding to immunostaining of both E-cadherin & P53, there was a highly significant difference between lesional biopsies of cases and control groups. Also there was a highly significant difference between lesional biopsies of cases and perilesional and non lesional biopsies of the same cases. No significant difference was noted regarding the disease stability. Conclusion: vitiligo is not a disease confined to melanocytes. Keratinocytes apoptosis and impaired cell to cell adhesion may play prominent role in the pathogenesis of the disease.

Issued also as CD

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