Study of serum syndecan-1 levels in juvenile systemic lupus erythematosus (JSLE) Egyptian patients / Rasha Hossam Eldin Mahfouz ; Supervised Naglaa Abdelrahman Mosaad , Hala Mohamed Lotfy , Rasha Mohamad Hosny Shahin

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Rasha Hossam Eldin Mahfouz

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TextLanguage: English Publication details: Cairo : Rasha Hossam Eldin Mahfouz , 2016Description: 122 P. : charts , facsimiles ; 25cmOther title:

دراسة نسبة السينديكان-1 في الأطفال المصريين المصابين بالذئبه الحمراء [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Systemic Lupus Erythematosus (SLE) is characterized by loss of B-cell tolerance so Syndecan-1 (SDC-1) which is expressed on plasma cells derived from B-cells is thought to play a role in SLE . This is a cross-sectional study conducted on 60 JSLE patients and 30 healthy controls . Serum SDC-1 level was measured using ELISA technique and correlated with different clinical and laboratory data as well as SLEDAI-2K , renal SLEDAI , renal activity scores . Our results showed that Syndecan-1 is significantly higher in SLE patients compared with controls . Also, it has positive correlation with activity scores so it can be used as a marker for disease activity and renal activity in JSLE patients

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.28.M.Sc.2016.Ra.S (Browse shelf(Opens below))		Not for loan	01010110069683000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.28.M.Sc.2016.Ra.S (Browse shelf(Opens below))	69683.CD	Not for loan	01020110069683000

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Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Systemic Lupus Erythematosus (SLE) is characterized by loss of B-cell tolerance so Syndecan-1 (SDC-1) which is expressed on plasma cells derived from B-cells is thought to play a role in SLE . This is a cross-sectional study conducted on 60 JSLE patients and 30 healthy controls . Serum SDC-1 level was measured using ELISA technique and correlated with different clinical and laboratory data as well as SLEDAI-2K , renal SLEDAI , renal activity scores . Our results showed that Syndecan-1 is significantly higher in SLE patients compared with controls . Also, it has positive correlation with activity scores so it can be used as a marker for disease activity and renal activity in JSLE patients

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