header
Local cover image
Local cover image
Image from OpenLibrary

Immunohistochemical expression of galectin-1 in chondroblastic osteosarcoma and conventional chonrosarcoma in comparison with normal bone : Comparative in-vitro study / Ali Abdelwahed Abdelfatah Kotb ; Supervised Louloua Mohamed Fathy , Nermine Raouf Amin

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ali Abdelwahed Abdelfatah Kotb , 2016Description: 103 P. : charts , facsimiles ; 25cmOther title:
  • التعبيير المناعى النسيجى الكيميائى لبروتين جالكتين-١ فى السركومة العظمية الغضروفية و السركومة الغضروفية مقارنة مع العظم الطبيعى : دراسة معملية مقارنة [Added title page title]
Subject(s): Online resources: Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Surgery Summary: Osteosarcomas and chondrosarcomas are two of the most common types of primary bone malignancies. Osteosarcoma is the most common oral malignancy encountered by oral and maxillofacial pathologists after squamous cell carcinoma. Chondrosarcoma incidence as a primary bone malignancy usually comes following osteosarcoma. Osteosarcoma is a primary bone malignancy of mesenchymal stem cells that produces bone. Its diagnosis is based on the production of osteoid from the malignant cellular stroma. Chondrosarcoma on the other hand, is a malignant neoplasm that arises from mesenchymal cells that undergo partial differentiation to form chondroblastic tissue without osteoid production. Chondroblastic osteosarcoma is a type of osteosarcoma that forms pockets of osteoid in addition to chondroblastic differentiation. Chondroblastic osteosarcoma and chondrosarcoma are two overlapping tumors that are usually misdiagnosed due to the presence of chondroblastic tissue in both of them in addition to the presence of osteoid arising from the malignant stroma in the chondroblastic osteosarcoma. In the absence of a specific diagnostic marker that discriminates accurately between chondoblastic osteosarcoma and chondrosarcoma, misdiagnosis of both tumors might occur. Osteosarcoma treatment usually involves neoadjuvant chemotherapy followed by radical surgery, while chondrosarcoma is usually treated, only, by radical surgical resection. In general chondrosarcoma bears a better prognosis than osteosarcoma. Galectins are a large family of proteins. Only galectin-1, -2, -3, -4, -7, -8, -9, -10, -12 and -13 have been identified in humans. They have a long list of functions. In our study, we were concerned with GAL-1. GAL-1 was expressed in human osteoblasts, suggesting that GAL-1 reactivity might identify tumors of osteoblastic origin. Previous demonstrations showed GAL-1 expression in normal and malignant cells, consequently, this work used GAL-1 as a marker of the osteoblastic lineage rather than a marker of malignancy. In this project, we also analyzed the statistical difference in the immunohistochemical expression of GAL-1 in chondroblastic osteosarcoma and chondrosarcoma to serve as a dicriminitive diagnostic test for both tumors
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.09.13.M.Sc.2016.Al.I (Browse shelf(Opens below)) Not for loan 01010110072507000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.09.13.M.Sc.2016.Al.I (Browse shelf(Opens below)) 72507.CD Not for loan 01020110072507000

Browsing المكتبة المركزبة الجديدة - جامعة القاهرة shelves Close shelf browser (Hides shelf browser)

No cover image available
No cover image available
No cover image available
No cover image available
No cover image available
No cover image available
No cover image available
Cai01.09.13.M.Sc.2016.Al.C A comparative study of the effect of immediate loading versus delayed loading on crestal bone loss of delayed implantation in mandibular posterior region : Randomized controlled study / Cai01.09.13.M.Sc.2016.Al.C A comparative study of the effect of immediate loading versus delayed loading on crestal bone loss of delayed implantation in mandibular posterior region : Randomized controlled study / Cai01.09.13.M.Sc.2016.Al.I Immunohistochemical expression of galectin-1 in chondroblastic osteosarcoma and conventional chonrosarcoma in comparison with normal bone : Comparative in-vitro study / Cai01.09.13.M.Sc.2016.Al.I Immunohistochemical expression of galectin-1 in chondroblastic osteosarcoma and conventional chonrosarcoma in comparison with normal bone : Comparative in-vitro study / Cai01.09.13.M.Sc.2016.Ha.A Accuracy of cone beam computed tomography (CBCT) versus digital periapical radiography by photostimulated phosphor in detection of dental root fractures : Diagnostic study / Cai01.09.13.M.Sc.2016.Ha.A Accuracy of cone beam computed tomography (CBCT) versus digital periapical radiography by photostimulated phosphor in detection of dental root fractures : Diagnostic study / Cai01.09.13.M.Sc.2016.He.A Assessment of the preventive effect of grape seed extract on the inflammation of tongue mucosa caused by cetuximab drug in experimental rats : An animal study /

Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Surgery

Osteosarcomas and chondrosarcomas are two of the most common types of primary bone malignancies. Osteosarcoma is the most common oral malignancy encountered by oral and maxillofacial pathologists after squamous cell carcinoma. Chondrosarcoma incidence as a primary bone malignancy usually comes following osteosarcoma. Osteosarcoma is a primary bone malignancy of mesenchymal stem cells that produces bone. Its diagnosis is based on the production of osteoid from the malignant cellular stroma. Chondrosarcoma on the other hand, is a malignant neoplasm that arises from mesenchymal cells that undergo partial differentiation to form chondroblastic tissue without osteoid production. Chondroblastic osteosarcoma is a type of osteosarcoma that forms pockets of osteoid in addition to chondroblastic differentiation. Chondroblastic osteosarcoma and chondrosarcoma are two overlapping tumors that are usually misdiagnosed due to the presence of chondroblastic tissue in both of them in addition to the presence of osteoid arising from the malignant stroma in the chondroblastic osteosarcoma. In the absence of a specific diagnostic marker that discriminates accurately between chondoblastic osteosarcoma and chondrosarcoma, misdiagnosis of both tumors might occur. Osteosarcoma treatment usually involves neoadjuvant chemotherapy followed by radical surgery, while chondrosarcoma is usually treated, only, by radical surgical resection. In general chondrosarcoma bears a better prognosis than osteosarcoma. Galectins are a large family of proteins. Only galectin-1, -2, -3, -4, -7, -8, -9, -10, -12 and -13 have been identified in humans. They have a long list of functions. In our study, we were concerned with GAL-1. GAL-1 was expressed in human osteoblasts, suggesting that GAL-1 reactivity might identify tumors of osteoblastic origin. Previous demonstrations showed GAL-1 expression in normal and malignant cells, consequently, this work used GAL-1 as a marker of the osteoblastic lineage rather than a marker of malignancy. In this project, we also analyzed the statistical difference in the immunohistochemical expression of GAL-1 in chondroblastic osteosarcoma and chondrosarcoma to serve as a dicriminitive diagnostic test for both tumors

Issued also as CD

There are no comments on this title.

to post a comment.

Click on an image to view it in the image viewer

Local cover image
Share
Under the supervision of New Central Library Manager

Implemented and Customized by: Eng.M.Mohamady
Contact:   info@cl.cu.edu.eg

© All rights reserved  New Central Library