Enhancement of drug targeting using nanocarriers / Raghda Adel Abdelbadia Mohamed Elshenawy ; Supervised Wael Mohy Edin Elshemey , Heba Mohamed Fahmy , Mohamed Mahmoud Fathy
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TextLanguage: English Publication details: Cairo : Raghda Adel Abdelbadia Mohamed Elshenawy , 2019Description: 89 P. : charts ; 25cmOther title: - تحسين توجيه الأدوية عن طريق الحاملات النانومترية [Added title page title]
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قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.12.04.M.Sc.2019.Ra.E (Browse shelf(Opens below)) | Not for loan | 01010110079436000 | ||
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مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.12.04.M.Sc.2019.Ra.E (Browse shelf(Opens below)) | 79436.CD | Not for loan | 01020110079436000 |
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Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics
Nowadays, Nanotechnology is used to solve the problem of the delivery of pharmaceuticals to the brain which is restricted by the blood brain barrier. In this study we prepared silica nanoparticles (MSNs) for deliver. Thymoquinone (TQ), which used as a drug model. The prepared nanoparticles were examined using TEM, DLS, and Zeta potential. TEM revealed that the size of prepared nanoparticle was about80-120nm, which was confirmed using Dynamic light scattering (DLS) measurements. Zeta potential measurements were 30.8±2.34 mV for free silica nanoparticles and - 15.9±1.85 mV for loaded with TQ. Assessment the TQ distribution in different brain areas showed that the nano-carrier enhance the targeting of TQ to the brain by 13.24%, 11.47%, 19.88% and 70.78%than free TQ in cortex, thalamus, midbrain and hypothalamus respectively. In conclusion: The using silica nanoparticlese increase the drug bioavailability to the brain
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