Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine

Aims Evaluation of the safety and efficacy of PVI in PAF patients using two new different technologies, cryoballoon ablation and RFA with contact force-sensing catheters. Methods and results We performed a prospective single centre non-randomized controlled clinical trial that was conducted during the period between January 2016 and June 2018 in Critical Care Medicine Department{u2013} Cairo University.Twenty patients were enrolled in this study and were subjected to standardized PVI using RFA with CF sensing catheter (Thermocool® SmartTouch{u2122}, Biosense Webster (CF group, n=10 patients) and CB ablation (Arctic Front Advance{u2122}, Medtronic)(CB group n=10 patients).Twelve months follow up was used to assess procedure long term outcome and complications rate. Procedure duration was significantly shorter for CB group than for CF group (171.7+15.24 vs. 199.3+18.94 min, P = 0.002), however fluoroscopy duration and X-ray exposure were longer in CB group than CF group , however was not statistically significant (P = 0.1 and P = 0.22, respectively). Overall complication rate was similar in both groups: 2 (20%) in each group. Transient right phrenic nerve palsy occurred only in CB group (1 patient,10% vs none in the CF group); and transient ischemic acute stroke occurred only in one patient of the CB group (10% vs none in the CF group) ,severe non-lethal complications (Tamponade, and the uncommon complication, entrapment of circular mapping catheter into mitral valve ) occurred only in CF group (2 patients, 20%)

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