Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

This work investigates the possible protective role of curcumin and selenium (Se), considered as antioxidants, singly or in combination in ameliorating cadmium (Cd) induced teratogenicity. Cadmium (18.4mg / kg, p.o) was given from day 7 to 16 of gestation. Curcumin (50mg / kg, p.o), Se (18æg / Kg, p.o) or their combination were administered all over the period of gestation with or without Cd insult. The results showed decrease in maternal body weight gain, increase in the rate of abortion, resorption and growth retardation of fetuses and malformations in their skeleton in group received Cd. Besides, there were significant decrease in red blood cells, and hemoglobin concentration while increase in the white blood cells count. Serum levels of AST, ALT, LDH, urea and creatinine showed significant elevation in mothers and their fetuses compared to the normal control group

Issued also as CD