The prognostic value of adenosine triphosphate (ATP) binding Cassette (ABCB5) and Multidrug resistance (MDR1) genes` expression in acute leukemias / Hebat Allah Ahmed Mahmoud Ahmed ; Supervised Hala M. Farawela , Hamdy M. Zawam , Mervat M. Khorshied

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Hebat Allah Ahmed Mahmoud Ahmed

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Material type: Text

TextLanguage: English Publication details: Cairo : Hebat Allah Ahmed Mahmoud Ahmed , 2014Description: 264 P. : charts , facsimiles ; 25cmOther title:

القيمه التعبيريه و النذيره لجينات ادينوسين ثلاثى الفوسفات كاسيت الملزم (ايه بى س بى 5) و لتحديد المقاومه المتعدده للادويه1(ام دى ار 1) فى سرطان الدم الحاد [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Multidrug resistance represents a major obstacle in the chemotherapeutic treatment of acute leukemia (AL). Adenosine triphosphate ATP - binding cassette (ABCB5) and multidrug resistance (MDR1) genes are integral membrane proteins belonging to ATP - binding cassette transporters superfamily. The present work aimed to investigate the impact of ABCB5 and MDR1 genes expression on the response to chemotherapy in a cohort of Egyptian acute leukemia patients. The study included 90 patients; 53 AML cases and 37 ALL cases in addition to 20 healthy volunteers as controls. Quantitative assessment of MDR1 and ABCB5 genes expression was performed by quantitative real-time polymerase chain reaction qPCR

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.He.P (Browse shelf(Opens below))		Not for loan	01010110064514000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.He.P (Browse shelf(Opens below))	64514.CD	Not for loan	01020110064514000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Multidrug resistance represents a major obstacle in the chemotherapeutic treatment of acute leukemia (AL). Adenosine triphosphate ATP - binding cassette (ABCB5) and multidrug resistance (MDR1) genes are integral membrane proteins belonging to ATP - binding cassette transporters superfamily. The present work aimed to investigate the impact of ABCB5 and MDR1 genes expression on the response to chemotherapy in a cohort of Egyptian acute leukemia patients. The study included 90 patients; 53 AML cases and 37 ALL cases in addition to 20 healthy volunteers as controls. Quantitative assessment of MDR1 and ABCB5 genes expression was performed by quantitative real-time polymerase chain reaction qPCR

Issued also as CD

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